Back
Full-text
Journal article

ACVIM consensus statement: Support for rational administration of gastrointestinal protectants to dogs and cats.

  • Marks SL Department of Medicine & Epidemiology, School of Veterinary Medicine, University of California, Davis, Davis, California.
  • Kook PH Vetsuisse Faculty, Clinic for Small Animal Internal Medicine, Vetsuisse Faculty, University of Zurich, Zurich, Switzerland.
  • Papich MG Department of Molecular Biomedical Sciences, North Carolina State University, College of Veterinary Medicine, Raleigh, North Carolina.
  • Tolbert MK Department of Small Animal Clinical Sciences, College of Veterinary Medicine, Texas A & M University, College Station, Texas.
  • Willard MD Department of Small Animal Clinical Sciences, College of Veterinary Medicine, Texas A & M University, College Station, Texas.
  • 2018-11-01
Published in:
  • Journal of veterinary internal medicine. - 2018
acid
canine
feline
gastroesophageal reflux
histamine type-2 receptor antagonist
misoprostol
proton pump inhibitor
sucralfate
ulcer
Animals
Cat Diseases
Cats
Dog Diseases
Dogs
Gastrointestinal Agents
Gastrointestinal Diseases
Misoprostol
Proton Pump Inhibitors
Sucralfate
English The gastrointestinal (GI) mucosal barrier is continuously exposed to noxious toxins, reactive oxygen species, microbes, and drugs, leading to the development of inflammatory, erosive, and ultimately ulcerative lesions. This report offers a consensus opinion on the rational administration of GI protectants to dogs and cats, with an emphasis on proton pump inhibitors (PPIs), histamine type-2 receptor antagonists (H2 RAs), misoprostol, and sucralfate. These medications decrease gastric acidity or promote mucosal protective mechanisms, transforming the management of dyspepsia, peptic ulceration, and gastroesophageal reflux disease. In contrast to guidelines that have been established in people for the optimal treatment of gastroduodenal ulcers and gastroesophageal reflux disease, effective clinical dosages of antisecretory drugs have not been well established in the dog and cat to date. Similar to the situation in human medicine, practice of inappropriate prescription of acid suppressants is also commonplace in veterinary medicine. This report challenges the dogma and clinical practice of administering GI protectants for the routine management of gastritis, pancreatitis, hepatic disease, and renal disease in dogs and cats lacking additional risk factors for ulceration or concerns for GI bleeding. Judicious use of acid suppressants is warranted considering recent studies that have documented adverse effects of long-term supplementation of PPIs in people and animals.
Language
  • English
Open access status
gold
Identifiers
Persistent URL
https://folia.unifr.ch/global/documents/133007
Statistics
Document views: 60 File downloads:
  • Full-text: 0