Journal article
3-Dimensional magnetic resonance imaging of the freely moving human eye.
- Franceschiello B The Laboratory for Investigative Neurophysiology (The LINE), Department of Radiology, University Hospital Center and University of Lausanne, Lausanne, Switzerland; Department of Ophthalmology, University of Lausanne, Jules Gonin Eye Hospital, Fondation Asile des aveugles, Lausanne, Switzerland. Electronic address: Benedetta.franceschiello@fa2.ch.
- Di Sopra L Department of Radiology, University Hospital Center and University of Lausanne, Lausanne, Switzerland.
- Minier A The Laboratory for Investigative Neurophysiology (The LINE), Department of Radiology, University Hospital Center and University of Lausanne, Lausanne, Switzerland; Department of Ophthalmology, University of Lausanne, Jules Gonin Eye Hospital, Fondation Asile des aveugles, Lausanne, Switzerland.
- Ionta S Department of Ophthalmology, University of Lausanne, Jules Gonin Eye Hospital, Fondation Asile des aveugles, Lausanne, Switzerland.
- Zeugin D The Laboratory for Investigative Neurophysiology (The LINE), Department of Radiology, University Hospital Center and University of Lausanne, Lausanne, Switzerland; Department of Ophthalmology, University of Lausanne, Jules Gonin Eye Hospital, Fondation Asile des aveugles, Lausanne, Switzerland.
- Notter MP The Laboratory for Investigative Neurophysiology (The LINE), Department of Radiology, University Hospital Center and University of Lausanne, Lausanne, Switzerland.
- Bastiaansen JAM Department of Radiology, University Hospital Center and University of Lausanne, Lausanne, Switzerland.
- Jorge J École Polytechnique Fédérale de Lausanne (EPFL) Lausanne, Switzerland.
- Yerly J Department of Radiology, University Hospital Center and University of Lausanne, Lausanne, Switzerland; Center for Biomedical Imaging (CIBM), Lausanne, Switzerland.
- Stuber M Department of Radiology, University Hospital Center and University of Lausanne, Lausanne, Switzerland; Center for Biomedical Imaging (CIBM), Lausanne, Switzerland.
- Murray MM The Laboratory for Investigative Neurophysiology (The LINE), Department of Radiology, University Hospital Center and University of Lausanne, Lausanne, Switzerland; Department of Ophthalmology, University of Lausanne, Jules Gonin Eye Hospital, Fondation Asile des aveugles, Lausanne, Switzerland; Center for Biomedical Imaging (CIBM), Lausanne, Switzerland; Department of Hearing and Speech Sciences, Vanderbilt University Nashville, TN, USA. Electronic address: micah.murray@chuv.ch.
- 2020-07-13
Published in:
- Progress in neurobiology. - 2020
English
Eye motion is a major confound for magnetic resonance imaging (MRI) in neuroscience or ophthalmology. Currently, solutions toward eye stabilisation include participants fixating or administration of paralytics/anaesthetics. We developed a novel MRI protocol for acquiring 3-dimensional images while the eye freely moves. Eye motion serves as the basis for image reconstruction, rather than an impediment. We fully reconstruct videos of the moving eye and head. We quantitatively validate data quality with millimetre resolution in two ways for individual participants. First, eye position based on reconstructed images correlated with simultaneous eye-tracking. Second, the reconstructed images preserve anatomical properties; the eye's axial length measured from MRI images matched that obtained with ocular biometry. The technique operates on a standard clinical setup, without necessitating specialized hardware, facilitating wide deployment. In clinical practice, we anticipate that this may help reduce burdens on both patients and infrastructure, by integrating multiple varieties of assessments into a single comprehensive session. More generally, our protocol is a harbinger for removing the necessity of fixation, thereby opening new opportunities for ethologically-valid, naturalistic paradigms, the inclusion of populations typically unable to stably fixate, and increased translational research such as in awake animals whose eye movements constitute an accessible behavioural readout.
- Language
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- English
- Open access status
- green
- Identifiers
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- DOI 10.1016/j.pneurobio.2020.101885
- PMID 32653462
- Persistent URL
- https://folia.unifr.ch/global/documents/13204
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