Journal article
Endocrine disrupting compounds: can they target the immune system of fish?
- Casanova-Nakayama A Centre for Fish and Wildlife Health, Vetsuisse Faculty, University of Bern, 3001 Bern, Switzerland. ayako.casanova@vetsuisse.unibe.ch
- Wenger M
- Burki R
- Eppler E
- Krasnov A
- Segner H
- 2011-06-21
Published in:
- Marine pollution bulletin. - 2011
Animals
Endocrine Disruptors
Fishes
Gene Expression
Immune System
Immunity, Innate
Immunomodulation
Water Pollutants, Chemical
English
Endocrine disruption, in particular disruption by estrogen-active compounds, has been identified as an important ecotoxicological hazard in the aquatic environment. Research on the impact of endocrine disrupting compounds (EDCs) on wildlife has focused on disturbances of the reproductive system. However, there is increasing evidence that EDCs affect a variety of physiological systems other than the reproductive system. Here, we discuss if EDCs may be able to affect the immune system of fish, as this would have direct implications for individual fitness and population growth. Evidence suggesting an immunomodulatory role of estrogens in fish comes from the following findings: (a) estrogen receptors are expressed in piscine immune organs, (b) immune gene expression is modulated by estrogen exposure, and (c) pathogen susceptibility of fish increases under estrogen exposure.
- Language
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- English
- Open access status
- closed
- Identifiers
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- DOI 10.1016/j.marpolbul.2011.05.007
- PMID 21683417
- Persistent URL
- https://folia.unifr.ch/global/documents/131619
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