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Harnessing the immune system to fight cancer with Toll-like receptor and RIG-I-like receptor agonists.

  • Bourquin C Chair of Pharmacology, Faculty of Science, University of Fribourg, 1700, Fribourg, Switzerland; Institute of Pharmaceutical Sciences, University of Geneva, University of Lausanne, 1211, Geneva, Switzerland; Department of Anesthesiology, Pharmacology and Intensive Care, Faculty of Medicine, University of Geneva, 1211, Geneva, Switzerland. Electronic address: carole.bourquin@unige.ch.
  • Pommier A Institute of Pharmaceutical Sciences, University of Geneva, University of Lausanne, 1211, Geneva, Switzerland.
  • Hotz C Chair of Pharmacology, Faculty of Science, University of Fribourg, 1700, Fribourg, Switzerland.
  • 2019-03-06
Published in:
  • Pharmacological research. - 2020
852A (PubChem CID: 134827873)
Agatolimod (PubChem CID: 56841790)
Cancer immunotherapy
Imiquimod (PubChem CID: 57469)
MEDI9197 (PubChem CID: 56833311)
Motolimod (PubChem CID: 16049404)
Nanoparticle delivery
RIG-I like receptors
Toll-like receptors
English Cancer immunotherapy has come of age with the advent of immune checkpoint inhibitors. In this article we review how agonists for receptors of the innate immune system, the Toll-like receptors and the RIG-I-like receptors, impact anticancer immune responses. Treatment with these agonists enhances the activity of anticancer effector cells, such as cytotoxic T cells and NK cells, and at the same time blocks the activity of immunosuppressive cell types such as regulatory T cells and myeloid-derived suppressor cells. These compounds also impact the recruitment of immune cells to the tumor. The phenomena of pattern-recognition receptor tolerance and reprogramming and their implications for immunotherapy are discussed. Finally, novel delivery systems that target the immune-stimulating drugs to the tumor or the tumor-draining lymph nodes to enhance their efficacy and safety are presented.
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  • English
Open access status
green
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https://folia.unifr.ch/global/documents/131082
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