Journal article

CheckMate 141: 1-Year Update and Subgroup Analysis of Nivolumab as First-Line Therapy in Patients with Recurrent/Metastatic Head and Neck Cancer.

  • Gillison ML MD Anderson Cancer Center, Houston, Texas, USA mgillison@mdanderson.org.
  • Blumenschein G MD Anderson Cancer Center, Houston, Texas, USA.
  • Fayette J Centre Leon Berard, Lyon, France.
  • Guigay J Centre Antoine Lacassagne, FHU OncoAge, Université Côte d'Azur, Nice, France.
  • Colevas AD Stanford University, Stanford, California, USA.
  • Licitra L Fondazione IRCCS Istituto Nazionale dei Tumori and University of Milan, Milan, Italy.
  • Harrington KJ Royal Marsden NHS Foundation Trust/The Institute of Cancer Research, National Institute of Health Research Biomedical Research Centre, London, United Kingdom.
  • Kasper S West German Cancer Center, University Hospital, Essen, Germany.
  • Vokes EE University of Chicago Medicine and Biological Sciences, Chicago, Illinois, USA.
  • Even C Gustave Roussy, Villejuif Cedex, France.
  • Worden F University of Michigan, Ann Arbor, Michigan, USA.
  • Saba NF Winship Cancer Institute of Emory University, Atlanta, Georgia, USA.
  • Iglesias Docampo LC Hospital Universitario 12 de Octubre, Madrid, Spain.
  • Haddad R Dana-Farber/Harvard Cancer Center, Boston, Massachusetts, USA.
  • Rordorf T Universitätsspital Zurich, Zurich, Switzerland.
  • Kiyota N Kobe University Hospital Cancer Center, Kobe, Japan.
  • Tahara M National Cancer Center Hospital East, Kashiwa, Japan.
  • Monga M Bristol-Myers Squibb, Princeton, New Jersey, USA.
  • Lynch M Bristol-Myers Squibb, Princeton, New Jersey, USA.
  • Li L Bristol-Myers Squibb, Princeton, New Jersey, USA.
  • Ferris RL University of Pittsburgh Medical Center Hillman Cancer Center, Pittsburgh, Pennsylvania, USA.
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  • 2018-06-06
Published in:
  • The oncologist. - 2018
English Nivolumab significantly improved overall survival (OS) vs investigator's choice (IC) of chemotherapy at the primary analysis of randomized, open-label, phase 3 CheckMate 141 in patients with recurrent or metastatic (R/M) squamous cell carcinoma of the head and neck (SCCHN). Here, we report that OS benefit with nivolumab was maintained at a minimum follow-up of 11.4 months. Further, OS benefit with nivolumab vs IC was also noted among patients who received first-line treatment for R/M SCCHN after progressing on platinum therapy for locally advanced disease in the adjuvant or primary (i.e., with radiation) setting.
Language
  • English
Open access status
bronze
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Persistent URL
https://folia.unifr.ch/global/documents/128572
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