CheckMate 141: 1-Year Update and Subgroup Analysis of Nivolumab as First-Line Therapy in Patients with Recurrent/Metastatic Head and Neck Cancer.
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Gillison ML
MD Anderson Cancer Center, Houston, Texas, USA mgillison@mdanderson.org.
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Blumenschein G
MD Anderson Cancer Center, Houston, Texas, USA.
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Fayette J
Centre Leon Berard, Lyon, France.
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Guigay J
Centre Antoine Lacassagne, FHU OncoAge, Université Côte d'Azur, Nice, France.
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Colevas AD
Stanford University, Stanford, California, USA.
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Licitra L
Fondazione IRCCS Istituto Nazionale dei Tumori and University of Milan, Milan, Italy.
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Harrington KJ
Royal Marsden NHS Foundation Trust/The Institute of Cancer Research, National Institute of Health Research Biomedical Research Centre, London, United Kingdom.
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Kasper S
West German Cancer Center, University Hospital, Essen, Germany.
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Vokes EE
University of Chicago Medicine and Biological Sciences, Chicago, Illinois, USA.
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Even C
Gustave Roussy, Villejuif Cedex, France.
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Worden F
University of Michigan, Ann Arbor, Michigan, USA.
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Saba NF
Winship Cancer Institute of Emory University, Atlanta, Georgia, USA.
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Iglesias Docampo LC
Hospital Universitario 12 de Octubre, Madrid, Spain.
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Haddad R
Dana-Farber/Harvard Cancer Center, Boston, Massachusetts, USA.
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Rordorf T
Universitätsspital Zurich, Zurich, Switzerland.
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Kiyota N
Kobe University Hospital Cancer Center, Kobe, Japan.
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Tahara M
National Cancer Center Hospital East, Kashiwa, Japan.
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Monga M
Bristol-Myers Squibb, Princeton, New Jersey, USA.
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Lynch M
Bristol-Myers Squibb, Princeton, New Jersey, USA.
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Li L
Bristol-Myers Squibb, Princeton, New Jersey, USA.
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Ferris RL
University of Pittsburgh Medical Center Hillman Cancer Center, Pittsburgh, Pennsylvania, USA.
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English
Nivolumab significantly improved overall survival (OS) vs investigator's choice (IC) of chemotherapy at the primary analysis of randomized, open-label, phase 3 CheckMate 141 in patients with recurrent or metastatic (R/M) squamous cell carcinoma of the head and neck (SCCHN). Here, we report that OS benefit with nivolumab was maintained at a minimum follow-up of 11.4 months. Further, OS benefit with nivolumab vs IC was also noted among patients who received first-line treatment for R/M SCCHN after progressing on platinum therapy for locally advanced disease in the adjuvant or primary (i.e., with radiation) setting.
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Language
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Open access status
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bronze
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Identifiers
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Persistent URL
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https://folia.unifr.ch/global/documents/128572
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