Journal article
Plasma concentrations of transdermal fentanyl and buprenorphine in pigs (Sus scrofa domesticus).
- Osorio Lujan S Heart Institute, Department of Pediatrics, Children's Hospital Colorado & University of Colorado, Aurora, CO, USA. Electronic address: Suzanne.osoriolujan@childrenscolorado.org.
- Habre W Unit for Anaesthesiological Investigations, Geneva University Hospitals and University of Geneva, Geneva, Switzerland.
- Daali Y Clinical Pharmacology and Toxicology Department, University of Geneva, Geneva, Switzerland.
- Pan Z Research Institute, Department of Pediatrics, University of Colorado School of Medicine, Aurora, CO, USA.
- Kronen PW Veterinary Anaesthesia Services-International, Winterthur and Center for Applied Biotechnology and Molecular Medicine, University of Zürich, Zürich, Switzerland.
- 2017-05-21
Published in:
- Veterinary anaesthesia and analgesia. - 2017
analgesia
buprenorphine
fentanyl
swine
transdermal patch
Administration, Cutaneous
Analgesics, Opioid
Animals
Buprenorphine
Female
Fentanyl
Random Allocation
Swine
Time Factors
English
OBJECTIVE
To determine the absorption characteristics of fentanyl and buprenorphine administered transdermally in swine.
STUDY DESIGN
A randomized comparative experimental trial.
ANIMALS
Twenty-four Yorkshire gilts weighing 27.8±2.2 kg (mean±standard deviation).
METHODS
Animals were randomly assigned to different doses of transdermal patches (TPs) of fentanyl (50 μg hour-1, 75 μg hour-1 and 100 μg hour-1) or buprenorphine (35 μg hour-1 and 70 μg hour-1), once or twice. Thirteen blood samples were obtained for each TP applied. Plasma concentrations were determined, and the area under the curve, peak serum concentration (Cmax) and time to Cmax were calculated.
RESULTS
Fentanyl: Cmax was observed at different time points: for the first TP application: 30 hours for 50 μg hour-1, 6 hours for 75 μg hour-1 and 100 μg hour-1 patches; and for the second TP application: 30 hours for 50 μg hour-1 and 36 hours for 75 μg hour-1 patches. Buprenorphine: serum concentrations were not detected for the 35 μg hour-1 patch; Cmax was observed at different times for the 70 μg hour-1 patch: 18 hours (n = 1), 24 hours (n = 3), 30 hours (n = 1) and 42 hours (n = 1) after application of the first patch and 12 hours after the second patch.
CONCLUSIONS AND CLINICAL RELEVANCE
A relevant serum concentration obtained with fentanyl TP dosed at 75 μg hour-1 or 100 μg hour-1suggests that TPs could represent an analgesia option for laboratory pigs weighing 25-30 kg. As concentrations of buprenorphine were variable, this study does not support the use of buprenorphine TPs in pigs. Consecutive fentanyl or buprenorphine TPs did not provide reliable serum concentrations. Further pharmacokinetic studies and analgesiometric tests in swine are needed to confirm the clinical adequacy of TPs.
To determine the absorption characteristics of fentanyl and buprenorphine administered transdermally in swine.
STUDY DESIGN
A randomized comparative experimental trial.
ANIMALS
Twenty-four Yorkshire gilts weighing 27.8±2.2 kg (mean±standard deviation).
METHODS
Animals were randomly assigned to different doses of transdermal patches (TPs) of fentanyl (50 μg hour-1, 75 μg hour-1 and 100 μg hour-1) or buprenorphine (35 μg hour-1 and 70 μg hour-1), once or twice. Thirteen blood samples were obtained for each TP applied. Plasma concentrations were determined, and the area under the curve, peak serum concentration (Cmax) and time to Cmax were calculated.
RESULTS
Fentanyl: Cmax was observed at different time points: for the first TP application: 30 hours for 50 μg hour-1, 6 hours for 75 μg hour-1 and 100 μg hour-1 patches; and for the second TP application: 30 hours for 50 μg hour-1 and 36 hours for 75 μg hour-1 patches. Buprenorphine: serum concentrations were not detected for the 35 μg hour-1 patch; Cmax was observed at different times for the 70 μg hour-1 patch: 18 hours (n = 1), 24 hours (n = 3), 30 hours (n = 1) and 42 hours (n = 1) after application of the first patch and 12 hours after the second patch.
CONCLUSIONS AND CLINICAL RELEVANCE
A relevant serum concentration obtained with fentanyl TP dosed at 75 μg hour-1 or 100 μg hour-1suggests that TPs could represent an analgesia option for laboratory pigs weighing 25-30 kg. As concentrations of buprenorphine were variable, this study does not support the use of buprenorphine TPs in pigs. Consecutive fentanyl or buprenorphine TPs did not provide reliable serum concentrations. Further pharmacokinetic studies and analgesiometric tests in swine are needed to confirm the clinical adequacy of TPs.
- Language
-
- English
- Open access status
- closed
- Identifiers
-
- DOI 10.1016/j.vaa.2016.09.002
- PMID 28526486
- Persistent URL
- https://folia.unifr.ch/global/documents/128382
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