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Cu(I)-catalyzed intramolecular cyclization of alkynoic acids in aqueous media: a "click side reaction".
Journal article

Cu(I)-catalyzed intramolecular cyclization of alkynoic acids in aqueous media: a "click side reaction".

  • Mindt TL Department of Chemistry and Applied Biosciences, ETH Zurich, 8093 Zurich, Switzerland. thomas.mindt@pharma.ethz.ch
  • Schibli R
  • 2007-11-30
Published in:
  • The Journal of organic chemistry. - 2007
Alkynes
Carboxylic Acids
Catalysis
Copper
Cyclization
Lactones
Molecular Structure
Stereoisomerism
Water
English Alkynoic acids, in particular, 4-pentynoic acid derivatives, undergo intramolecular cyclizations to enol lactones under reaction conditions typically applied for the Cu(I)-catalyzed cycloaddition of terminal alkynes and azides (click chemistry). Starting from appropriate alkynoic acid derivatives, either enol lactones or 1,2,3-triazole click products can be obtained selectively by Cu(I) catalysis in aqueous media.
Language
  • English
Open access status
closed
Identifiers
Persistent URL
https://folia.unifr.ch/global/documents/128125
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