Journal article
Role of 18F-FDG PET/CT Imaging in Intrahepatic Cholangiocarcinoma.
- Jiang L From the *Department of Nuclear Medicine, Zhongshan Hospital, Fudan University; †Nuclear Medicine Institute of Fudan University; and ‡Shanghai Institute of Medical Imaging, Shanghai, China; and §St Gallen Cantonal Hospital, St Gallen, Switzerland.
- Tan H
- Panje CM
- Yu H
- Xiu Y
- Shi H
- 2015-09-25
Published in:
- Clinical nuclear medicine. - 2016
Adult
Aged
Aged, 80 and over
Bile Duct Neoplasms
Bile Ducts, Intrahepatic
Biomarkers, Tumor
Carcinoma, Hepatocellular
Cholangiocarcinoma
Female
Fluorodeoxyglucose F18
Humans
Klatskin Tumor
Liver Neoplasms
Magnetic Resonance Imaging
Male
Middle Aged
Multimodal Imaging
Positron-Emission Tomography
Retrospective Studies
Sensitivity and Specificity
Tomography, X-Ray Computed
English
PURPOSE
Although intrahepatic cholangiocarcinoma (ICC) is the second most common primary hepatic malignancy after hepatocellular carcinoma, there are limited data available on PET/CT imaging in ICC. This retrospective study analyzed the role of PET/CT imaging in the evaluation of ICC.
METHODS
FDG PET/CT findings were reviewed in 65 patients with histologically confirmed ICC. PET/CT was evaluated based on visual interpretation and the semiquantitative index of SUVmax and tumor-to-normal liver tissue ratio (TNR), which were consequently further analyzed and correlated with tumor localization, differentiation, size, and serum levels of tumor markers. Forty-five cases also underwent abdominal MRI examinations.
RESULTS
Nineteen patients had hilar ICC, whereas 46 patients had peripheral ICC. Sixty cases of ICC showed elevated FDG uptake with an average SUVmax of 8.3 ± 4.7 and TNR of 3.1 ± 1.7. Five cases located in the hilum were false negative on PET/CT imaging. Compared with hilar ICC, SUVmax and TNR of peripheral ICC were significantly higher (P < 0.05). FDG accumulation correlated with the degree of ICC differentiation. SUVmax and TNR correlated with tumor size, whereas there was no correlation observed with serum levels of carbohydrate antigen 19-9. The sensitivity, specificity, and accuracy of PET/CT and MRI in the diagnosis of regional lymph node metastases were 70.0% versus 50%, 91.7% versus 83.3%, and 81.8% versus 68.2%, respectively. PET/CT upstaged 12.3% and downstaged 3.1% of cases and had no impact on patient management in the remaining 84.6% of cases.
CONCLUSIONS
Combination of FDG PET/CT and abdominal MRI might improve the diagnostic accuracy for ICC.
Although intrahepatic cholangiocarcinoma (ICC) is the second most common primary hepatic malignancy after hepatocellular carcinoma, there are limited data available on PET/CT imaging in ICC. This retrospective study analyzed the role of PET/CT imaging in the evaluation of ICC.
METHODS
FDG PET/CT findings were reviewed in 65 patients with histologically confirmed ICC. PET/CT was evaluated based on visual interpretation and the semiquantitative index of SUVmax and tumor-to-normal liver tissue ratio (TNR), which were consequently further analyzed and correlated with tumor localization, differentiation, size, and serum levels of tumor markers. Forty-five cases also underwent abdominal MRI examinations.
RESULTS
Nineteen patients had hilar ICC, whereas 46 patients had peripheral ICC. Sixty cases of ICC showed elevated FDG uptake with an average SUVmax of 8.3 ± 4.7 and TNR of 3.1 ± 1.7. Five cases located in the hilum were false negative on PET/CT imaging. Compared with hilar ICC, SUVmax and TNR of peripheral ICC were significantly higher (P < 0.05). FDG accumulation correlated with the degree of ICC differentiation. SUVmax and TNR correlated with tumor size, whereas there was no correlation observed with serum levels of carbohydrate antigen 19-9. The sensitivity, specificity, and accuracy of PET/CT and MRI in the diagnosis of regional lymph node metastases were 70.0% versus 50%, 91.7% versus 83.3%, and 81.8% versus 68.2%, respectively. PET/CT upstaged 12.3% and downstaged 3.1% of cases and had no impact on patient management in the remaining 84.6% of cases.
CONCLUSIONS
Combination of FDG PET/CT and abdominal MRI might improve the diagnostic accuracy for ICC.
- Language
-
- English
- Open access status
- closed
- Identifiers
-
- DOI 10.1097/RLU.0000000000000998
- PMID 26402131
- Persistent URL
- https://folia.unifr.ch/global/documents/125453
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