Journal article
Retinal Features in Cynomolgus Macaques (Macaca fascicularis) Assessed by Using Scanning Laser Ophthalmoscopy and Spectral Domain Optical Coherence Tomography
- Denk, Nora Pharma Research and Early Development (pRED), Pharmaceutical Sciences (PS), Roche Innovation Center Basel, Basel, Switzerland;, Email: nora.denk@roche.com
- Maloca, Peter M Institute of Molecular and Clinical Ophthalmology Basel (IOB), Basel, Switzerland; Moorfields Eye Hospital, London, United Kingdom; OCTlab Research Laboratory, Department of Ophthalmology, University of Basel, Basel, Switzerland
- Steiner, Guido Pharma Research and Early Development (pRED), Pharmaceutical Sciences (PS), Roche Innovation Center Basel, Basel, Switzerland
- Booler, Helen Genentech, South San Francisco, California
- Freichel, Christian Pharma Research and Early Development (pRED), Pharmaceutical Sciences (PS), Roche Innovation Center Basel, Basel, Switzerland
- Niklaus, Stephanie Pharma Research and Early Development (pRED), Pharmaceutical Sciences (PS), Roche Innovation Center Basel, Basel, Switzerland
- Schnitzer, Tobias K Pharma Research and Early Development (pRED), Pharmaceutical Sciences (PS), Roche Innovation Center Basel, Basel, Switzerland
- Hasler, Pascal W OCTlab Research Laboratory, Department of Ophthalmology, University of Basel, Basel, Switzerland
Published in:
- Comparative Medicine. - American Association for Laboratory Animal Science. - 2020, vol. 70, no. 2, p. 145-151
English
Cynomolgus macaques are an important and commonly used species in preclinical toxicology studies, but structural reports of in vivo retinal findings are rare in this species. The purpose of this study was to diminish this gap and document optical coherence tomography and scanning laser
ophthalmoscopy imaging data in the healthy posterior pole of cynomolgus monkeys' eyes at predose examinations. The current study is a retrospective assessment of baseline spectral domain OCT data obtained from the 768 eyes of 384 cynomolgus monkeys (192 males and 192 females) of Mauritian
origin. The data set was obtained from studies conducted over a 4-y period in the context of ocular safety evaluations of various compounds under preclinical development. The most prevalent findings were the presence of Bergmeister papilla and intravitreal hyperreflective spots. Less common
findings included disorganization of retinal zones, abnormalities of the retinal vasculature, partial posterior vitreous detachment, and abnormally shaped foveal pits. Thoughtful consideration of these physiologic findings will aid in distinguishing normal features from toxic outcomes in future
preclinical ophthalmic studies.
ophthalmoscopy imaging data in the healthy posterior pole of cynomolgus monkeys' eyes at predose examinations. The current study is a retrospective assessment of baseline spectral domain OCT data obtained from the 768 eyes of 384 cynomolgus monkeys (192 males and 192 females) of Mauritian
origin. The data set was obtained from studies conducted over a 4-y period in the context of ocular safety evaluations of various compounds under preclinical development. The most prevalent findings were the presence of Bergmeister papilla and intravitreal hyperreflective spots. Less common
findings included disorganization of retinal zones, abnormalities of the retinal vasculature, partial posterior vitreous detachment, and abnormally shaped foveal pits. Thoughtful consideration of these physiologic findings will aid in distinguishing normal features from toxic outcomes in future
preclinical ophthalmic studies.
- Language
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- English
- Open access status
- green
- Identifiers
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- DOI 10.30802/aalas-cm-19-000088
- ISSN 1532-0820
- Persistent URL
- https://folia.unifr.ch/global/documents/125301
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