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T cell fate specification and alphabeta/gammadelta lineage commitment.
Journal article

T cell fate specification and alphabeta/gammadelta lineage commitment.

  • MacDonald HR Ludwig Institute for Cancer Research, Lausanne Branch, University of Lausanne, CH-1066, Epalinges, Switzerland. HughRobson.MacDonald@isrec.unil.ch
  • Radtke F
  • Wilson A
  • 2001-03-03
Published in:
  • Current opinion in immunology. - 2001
Animals
Cell Differentiation
Cell Lineage
Dendritic Cells
Digestive System
Humans
Killer Cells, Natural
Receptors, Antigen, T-Cell, alpha-beta
Receptors, Antigen, T-Cell, gamma-delta
Stem Cells
T-Lymphocytes
English The development of T cells from pluripotent stem cells involves a coordinated series of lineage-commitment steps. Common lymphoid precursors in the fetal liver or adult bone marrow must first choose between a T, B or NK cell fate. Committed T cell precursors in the thymus then differentiate into cells committed to the alphabeta or gammadelta lineages. Recent advances have been made in our understanding of the mechanisms underlying T cell fate specification and alphabeta/gammadelta lineage divergence.
Language
  • English
Open access status
closed
Identifiers
Persistent URL
https://folia.unifr.ch/global/documents/124050
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