Journal article
Automated oligosaccharide synthesis.
- Seeberger PH Laboratory for Organic Chemistry, Swiss Federal Institute of Technology (ETH) Zürich, HCI F 315, Wolfgang-Pauli-Str. 10, CH-8093 Zürich, Switzerland. seeberger@org.chem.ethz.ch
- 2008-01-17
Published in:
- Chemical Society reviews. - 2008
Automation
Carbohydrate Conformation
Carbohydrate Sequence
Malaria Vaccines
Molecular Sequence Data
Oligosaccharides
English
Peptides and oligonucleotides are prepared by automated synthesizers that can be operated by non-specialists. Carbohydrates have been hard to assemble, but the increasing awareness of the biological importance of this class of complex repeating biopolymers has prompted efforts to accelerate their synthesis. This tutorial review defines the state of the art of automated solid phase oligosaccharide synthesis and identifies areas in need of further innovation. Application of the automated synthesis method to prepare a malaria vaccine candidate is briefly highlighted.
- Language
-
- English
- Open access status
- closed
- Identifiers
-
- DOI 10.1039/b511197h
- PMID 18197330
- Persistent URL
- https://folia.unifr.ch/global/documents/123647
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