Inner ear ossification and mineralization kinetics in human embryonic development - microtomographic and histomorphological study.
-
Richard C
ENT, Head and Neck Surgery Department, Lausanne University Hospital (CHUV), Lausanne, Switzerland. celine.richard@chuv.ch.
-
Courbon G
Laboratoire de Biologie des Tissus Ostéoarticulaires, INSERM, U1059 Sainbiose, Université de Lyon, Université Jean Monnet, Faculté de Médecine, Campus Santé Innovation, 42023, Saint-Étienne, France.
-
Laroche N
Laboratoire de Biologie des Tissus Ostéoarticulaires, INSERM, U1059 Sainbiose, Université de Lyon, Université Jean Monnet, Faculté de Médecine, Campus Santé Innovation, 42023, Saint-Étienne, France.
-
Prades JM
ENT, Head and Neck Surgery Department, Université de Lyon, Université Jean Monnet, CHU, Hôpital Nord, 42055, Saint-Étienne, France.
-
Vico L
Laboratoire de Biologie des Tissus Ostéoarticulaires, INSERM, U1059 Sainbiose, Université de Lyon, Université Jean Monnet, Faculté de Médecine, Campus Santé Innovation, 42023, Saint-Étienne, France.
-
Malaval L
Laboratoire de Biologie des Tissus Ostéoarticulaires, INSERM, U1059 Sainbiose, Université de Lyon, Université Jean Monnet, Faculté de Médecine, Campus Santé Innovation, 42023, Saint-Étienne, France.
Show more…
Published in:
- Scientific reports. - 2017
English
Little is known about middle and inner ear development during the second and third parts of human fetal life. Using ultra-high resolution Microcomputed Tomography coupled with bone histology, we performed the first quantitative middle and inner ear ossification/mineralization evaluation of fetuses between 17 and 39 weeks of gestational age. We show distinct ossification paces between ossicles, with a belated development of the stapes. A complete cochlear bony covering is observed within the time-frame of the onset of hearing, whereas distinct time courses of ossification for semicircular canal envelopes are observed in relation to the start of vestibular functions. The study evidences a spatio-temporal relationship between middle and inner ear structure development and the onset of hearing and balance, critical senses for the fetal adaptation to birth.
-
Language
-
-
Open access status
-
gold
-
Identifiers
-
-
Persistent URL
-
https://folia.unifr.ch/global/documents/123138
Statistics
Document views: 10
File downloads: