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Psilocybin induces schizophrenia-like psychosis in humans via a serotonin-2 agonist action.
Journal article

Psilocybin induces schizophrenia-like psychosis in humans via a serotonin-2 agonist action.

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  • 1999-01-06
Published in:
  • Neuroreport. - 1998
Adult
Analysis of Variance
Dose-Response Relationship, Drug
Female
Hallucinogens
Humans
Ketanserin
Male
Neuropsychological Tests
Psilocybin
Psychomotor Performance
Reaction Time
Reference Values
Schizophrenia
Serotonin Antagonists
Serotonin Receptor Agonists
English Psilocybin, an indoleamine hallucinogen, produces a psychosis-like syndrome in humans that resembles first episodes of schizophrenia. In healthy human volunteers, the psychotomimetic effects of psilocybin were blocked dose-dependently by the serotonin-2A antagonist ketanserin or the atypical antipsychotic risperidone, but were increased by the dopamine antagonist and typical antipsychotic haloperidol. These data are consistent with animal studies and provide the first evidence in humans that psilocybin-induced psychosis is due to serotonin-2A receptor activation, independently of dopamine stimulation. Thus, serotonin-2A overactivity may be involved in the pathophysiology of schizophrenia and serotonin-2A antagonism may contribute to therapeutic effects of antipsychotics.
Language
  • English
Open access status
closed
Identifiers
Persistent URL
https://folia.unifr.ch/global/documents/122186
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