Journal article
Chiral Cyclopentadienyl Cobalt(III) Complexes Enable Highly Enantioselective 3d-Metal-Catalyzed C-H Functionalizations.
- Ozols K Laboratory of Asymmetric Catalysis and Synthesis, Institute of Chemical Sciences and Engineering, École Polytechnique Fédérale de Lausanne (EPFL) , Lausanne CH-1015 , Switzerland.
- Jang YS Laboratory of Asymmetric Catalysis and Synthesis, Institute of Chemical Sciences and Engineering, École Polytechnique Fédérale de Lausanne (EPFL) , Lausanne CH-1015 , Switzerland.
- Cramer N Laboratory of Asymmetric Catalysis and Synthesis, Institute of Chemical Sciences and Engineering, École Polytechnique Fédérale de Lausanne (EPFL) , Lausanne CH-1015 , Switzerland.
- 2019-03-23
Published in:
- Journal of the American Chemical Society. - 2019
English
The synthesis of a set of cobalt(III)-complexes equipped with trisubstituted chiral cyclopentadienyl ligands is reported, and their steric and electronic parameters are mapped. The application potential of these complexes for asymmetric C-H functionalizations with 3d-metals is shown by the synthesis of dihydroisoquinolones from N-chlorobenzamides with a broad range of alkenes. The transformation proceeds with excellent enantioselectivities of up to 99.5:0.5 er and high regioselectivities. The observed values outperform the best rhodium(III)-based methods for this reaction type. Moreover, challenging substrates such as alkyl alkenes also react with high regio- and enantioselectivities.
- Language
-
- English
- Open access status
- closed
- Identifiers
-
- DOI 10.1021/jacs.9b02569
- PMID 30901216
- Persistent URL
- https://folia.unifr.ch/global/documents/120626
Statistics
Document views: 21
File downloads: