Journal article
Intrinsic excitation-inhibition imbalance affects medial prefrontal cortex differently in autistic men versus women.
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Trakoshis S
Laboratory for Autism and Neurodevelopmental Disorders, Center for Neuroscience and Cognitive Systems @UniTn, Istituto Italiano di Tecnologia, Rovereto, Italy.
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Martínez-Cañada P
Neural Computation Laboratory, Center for Neuroscience and Cognitive Systems @UniTn, Istituto Italiano di Tecnologia, Rovereto, Italy.
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Rocchi F
Functional Neuroimaging Laboratory, Center for Neuroscience and Cognitive Systems @UniTn, Istituto Italiano di Tecnologia, Rovereto, Italy.
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Canella C
Functional Neuroimaging Laboratory, Center for Neuroscience and Cognitive Systems @UniTn, Istituto Italiano di Tecnologia, Rovereto, Italy.
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You W
Artificial Intelligence and Image Processing Laboratory, Department of Information and Communications Engineering, Sun Moon University, Asan, Republic of Korea.
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Chakrabarti B
Autism Research Centre, Department of Psychiatry, University of Cambridge, Cambridge, United Kingdom.
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Ruigrok AN
Autism Research Centre, Department of Psychiatry, University of Cambridge, Cambridge, United Kingdom.
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Bullmore ET
Cambridgeshire and Peterborough National Health Service Foundation Trust, Cambridge, United Kingdom.
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Suckling J
Brain Mapping Unit, Department of Psychiatry, University of Cambridge, Cambridge, United Kingdom.
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Markicevic M
Neural Control of Movement Lab, D-HEST, ETH Zurich, Zurich, Switzerland.
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Zerbi V
Neural Control of Movement Lab, D-HEST, ETH Zurich, Zurich, Switzerland.
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Baron-Cohen S
Functional Neuroimaging Laboratory, Center for Neuroscience and Cognitive Systems @UniTn, Istituto Italiano di Tecnologia, Rovereto, Italy.
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Gozzi A
Autism Research Centre, Department of Psychiatry, University of Cambridge, Cambridge, United Kingdom.
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Lai MC
Neural Computation Laboratory, Center for Neuroscience and Cognitive Systems @UniTn, Istituto Italiano di Tecnologia, Rovereto, Italy.
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Panzeri S
Laboratory for Autism and Neurodevelopmental Disorders, Center for Neuroscience and Cognitive Systems @UniTn, Istituto Italiano di Tecnologia, Rovereto, Italy.
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Lombardo MV
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English
Excitation-inhibition (E:I) imbalance is theorized as an important pathophysiological mechanism in autism. Autism affects males more frequently than females and sex-related mechanisms (e.g., X-linked genes, androgen hormones) can influence E:I balance. This suggests that E:I imbalance may affect autism differently in males versus females. With a combination of in-silico modeling and in-vivo chemogenetic manipulations in mice, we first show that a time-series metric estimated from fMRI BOLD signal, the Hurst exponent (H), can be an index for underlying change in the synaptic E:I ratio. In autism we find that H is reduced, indicating increased excitation, in the medial prefrontal cortex (MPFC) of autistic males but not females. Increasingly intact MPFC H is also associated with heightened ability to behaviorally camouflage social-communicative difficulties, but only in autistic females. This work suggests that H in BOLD can index synaptic E:I ratio and that E:I imbalance affects autistic males and females differently.
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Language
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Open access status
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gold
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Identifiers
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Persistent URL
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https://folia.unifr.ch/global/documents/119260
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