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Intussusceptive angiogenesis: its emergence, its characteristics, and its significance.

  • Burri PH Institute of Anatomy, University of Berne, Buehlstrasse 26, CH-3012 Berne, Switzerland. burri@ana.unibe.ch
  • Hlushchuk R
  • Djonov V
  • 2004-09-18
Published in:
  • Developmental dynamics : an official publication of the American Association of Anatomists. - 2004
Animals
Blood Vessels
Capillaries
Chick Embryo
Chorion
Corrosion Casting
Humans
Microcirculation
Microscopy, Electron, Scanning
Models, Biological
Neovascularization, Physiologic
English This review shall familiarize the reader with the various aspects of intussusceptive angiogenesis (IA). The basic event in IA is the formation of transvascular tissue pillars. Depending on location, timing, and frequency of pillar emergence, the IA process has different outcomes. In capillaries, a primary IA function is to expand the capillary bed in size and complexity (intussusceptive microvascular growth). It represents an alternative to capillary sprouting. Highly ordered pillar formation in a developing capillary network leads to the formation of vascular trees (intussusceptive arborization). In small arteries and veins, pillar formation at the vessels' branching angles leads either to remodeling of the branching geometry or even to vascular pruning (intussusceptive branching remodeling). It appears essential that future angiogenic research considers always both phenomena, sprouting and intussusception. Vascularization of tissues, organs, and tumors rely heavily on both mechanisms; neglecting one or the other would obscure our understanding of the angiogenesis process.
Language
  • English
Open access status
bronze
Identifiers
Persistent URL
https://folia.unifr.ch/global/documents/114998
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