SIRT2- and NRF2-Targeting Thiazole-Containing Compound with Therapeutic Activity in Huntington's Disease Models.

• Quinti L Department of Neurology, Harvard Medical School and Massachusetts General Hospital, Boston, MA 02114, USA.
• Casale M Department of Neurobiology and Behavior, University of California, Irvine, CA 92697, USA.
• Moniot S Department of Biochemistry, University of Bayreuth, 95447 Bayreuth, Germany.
• Pais TF Cell and Molecular Neuroscience Unit, Instituto de Medicina Molecular, Avenida Professor Egas Moniz, 1649-028 Lisbon, Portugal.
• Van Kanegan MJ Department of Neurobiology, Center for Drug Discovery, Duke University Medical Center, Durham, NC 27710, USA.
• Kaltenbach LS Department of Neurobiology, Center for Drug Discovery, Duke University Medical Center, Durham, NC 27710, USA.
• Pallos J Department of Developmental and Cell Biology, University of California, Irvine, CA 92697, USA.
• Lim RG Department of Biological Chemistry, University of California, Irvine, CA 92697, USA.
• Naidu SD Division of Cancer Research, School of Medicine, University of Dundee, Dundee DD1 9SY, UK.
• Runne H Functional Neurogenomics, Brain Mind Institute, Ecole Polytechnique Fédérale de Lausanne, 1015 Lausanne, Switzerland.
• Meisel L Department of Biochemistry, University of Bayreuth, 95447 Bayreuth, Germany.
• Rauf NA Department of Neurology, Harvard Medical School and Massachusetts General Hospital, Boston, MA 02114, USA.
• Leyfer D Department of Neurology, Harvard Medical School and Massachusetts General Hospital, Boston, MA 02114, USA.
• Maxwell MM Department of Neurology, Harvard Medical School and Massachusetts General Hospital, Boston, MA 02114, USA.
• Saiah E BioTherapeutics Chemistry, Pfizer Worldwide Medicinal Chemistry, 200 Cambridge Park Drive, Cambridge, MA 02140, USA.
• Landers JE Department of Neurology, University of Massachusetts Medical School, Worcester, MA 01655, USA.
• Luthi-Carter R Functional Neurogenomics, Brain Mind Institute, Ecole Polytechnique Fédérale de Lausanne, 1015 Lausanne, Switzerland.
• Abagyan R Skaggs School of Pharmacy and Pharmaceutical Sciences, University of California, San Diego, CA 92093-0747, USA.
• Dinkova-Kostova AT Division of Cancer Research, School of Medicine, University of Dundee, Dundee DD1 9SY, UK; Departments of Medicine and Pharmacology and Molecular Sciences, Johns Hopkins University School of Medicine, Baltimore, MD 21205, USA.
• Steegborn C Department of Biochemistry, University of Bayreuth, 95447 Bayreuth, Germany.
• Marsh JL Department of Developmental and Cell Biology, University of California, Irvine, CA 92697, USA.
• Lo DC Department of Neurobiology, Center for Drug Discovery, Duke University Medical Center, Durham, NC 27710, USA.
• Thompson LM Department of Neurobiology and Behavior, University of California, Irvine, CA 92697, USA; Department of Biological Chemistry, University of California, Irvine, CA 92697, USA; Department of Psychiatry and Human Behavior, University of California, Irvine, CA 92697, USA.
• Kazantsev AG Department of Neurology, Harvard Medical School and Massachusetts General Hospital, Boston, MA 02114, USA. Electronic address: akazantsev47@gmail.com.

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Animals

Cell Line

Disease Models, Animal

Dose-Response Relationship, Drug

Drosophila

Huntington Disease

NF-E2-Related Factor 2

Neuroprotective Agents

Rats

Sirtuin 2

Structure-Activity Relationship

Thiazoles