Journal article
Oxidised phospholipids as biomarkers in human disease.
-
Philippova M
Department of Biomedicine, Laboratory for Signal Transduction, University Hospital Basel, University of Basel, Switzerland.
-
Resink T
Department of Biomedicine, Laboratory for Signal Transduction, University Hospital Basel, University of Basel, Switzerland.
-
Erne P
Hirslanden Klinik St. Anna, Luzern, Switzerland.
-
Bochkov V
Institute of Pharmaceutical Sciences, Pharmaceutical Chemistry, Karl-Franzens-University Graz, Austria.
Show more…
Published in:
- Swiss medical weekly. - 2014
English
Oxidised phospholipids (OxPLs) are generated from (poly)unsaturated diacyl- and alk(en)ylacyl glycerophospholipids under conditions of oxidative stress. OxPLs exert a wide variety of biological effects on diverse cell types in vitro and in vivo and are thought to play a role in the development of several chronic diseases including atherosclerosis, a classical lipid-associated and inflammatory disorder. OxPLs are recognised as culprit molecular components responsible for the pathophysiological actions of oxidised low-density lipoproteins. There is growing interest in the potential use of OxPLs as biomarkers of human pathologies. Here we offer a brief overview of current detection methods and knowledge on relationships between levels of circulating OxPLs and disease progression, with particular emphasis on cardiovascular disease.
-
Language
-
-
Open access status
-
gold
-
Identifiers
-
-
Persistent URL
-
https://folia.unifr.ch/global/documents/110898
Statistics
Document views: 9
File downloads: