Biomarkers and arrhythmia recurrence following radiofrequency ablation of atrial fibrillation.
- Carballo D 1 Division of Cardiology, Geneva University Hospitals, Geneva, Switzerland.
- Noble S 1 Division of Cardiology, Geneva University Hospitals, Geneva, Switzerland.
- Carballo S 2 Division of General Internal Medicine, Geneva University Hospitals, Geneva, Switzerland.
- Stirnemann J 2 Division of General Internal Medicine, Geneva University Hospitals, Geneva, Switzerland.
- Muller H 1 Division of Cardiology, Geneva University Hospitals, Geneva, Switzerland.
- Burri H 1 Division of Cardiology, Geneva University Hospitals, Geneva, Switzerland.
- Vuilleumier N 3 Division of Laboratory Medicine, Department of Genetics and Laboratory Medicine, Geneva University Hospitals, Geneva, Switzerland.
- Talajic M 4 Montreal Heart Institute, Université de Montréal, Canada.
- Tardif JC 4 Montreal Heart Institute, Université de Montréal, Canada.
- Keller PF 1 Division of Cardiology, Geneva University Hospitals, Geneva, Switzerland.
- Mach F 1 Division of Cardiology, Geneva University Hospitals, Geneva, Switzerland.
- Shah D 1 Division of Cardiology, Geneva University Hospitals, Geneva, Switzerland.
- 2018-09-05
Published in:
- The Journal of international medical research. - 2018
C-reactive protein
Catheter ablation
atrial fibrillation
atrial flutter
natriuretic peptides
recurrence
Atrial Fibrillation
Biomarkers
C-Reactive Protein
Female
Follow-Up Studies
Humans
Inflammation
Male
Middle Aged
Natriuretic Peptide, Brain
Peptide Fragments
Postoperative Complications
Prognosis
Prospective Studies
Radiofrequency Ablation
Recurrence
Risk Factors
Survival Rate
English
OBJECTIVE
Atrial fibrillation (AF) is the most common cardiac arrhythmia, and radiofrequency catheter ablation of AF (RCAAF) has become increasingly popular. Cardiac stress and inflammation have been associated with AF. This study was performed to determine whether the pre- or post-AF ablation levels of high-sensitivity C-reactive protein (hs-CRP) and N-terminal pro-B-type natriuretic peptide (NT-proBNP) are predictive of AF recurrence.
METHODS
This multicenter prospective cohort study involved patients undergoing RCAAF in Switzerland and Canada. The primary endpoint was the recurrence of AF or atrial flutter at 6 months.
RESULTS
Of 202 patients, 195 completed follow-up (age, 57.5 ± 9 years; mean left ventricular ejection fraction, 62%; mean left atrial size, 19.4 cm2). Patients with AF recurrence had larger atrial surfaces and longer total RCAAF times. Both the pre-ablation hs-CRP level and 1-day post-RCAAF NT-proBNP level were significantly associated with an increased risk of recurrence.
CONCLUSIONS
The pre-ablation hs-CRP level and immediate post-ablation NT-proBNP level were markers for atrial arrhythmia recurrence after RCAAF. This confirms growing evidence of the role of inflammation in the pathogenesis of AF. These biomarkers appear to be promising stratification tools for selection and management of patients undergoing RCAAF.
Atrial fibrillation (AF) is the most common cardiac arrhythmia, and radiofrequency catheter ablation of AF (RCAAF) has become increasingly popular. Cardiac stress and inflammation have been associated with AF. This study was performed to determine whether the pre- or post-AF ablation levels of high-sensitivity C-reactive protein (hs-CRP) and N-terminal pro-B-type natriuretic peptide (NT-proBNP) are predictive of AF recurrence.
METHODS
This multicenter prospective cohort study involved patients undergoing RCAAF in Switzerland and Canada. The primary endpoint was the recurrence of AF or atrial flutter at 6 months.
RESULTS
Of 202 patients, 195 completed follow-up (age, 57.5 ± 9 years; mean left ventricular ejection fraction, 62%; mean left atrial size, 19.4 cm2). Patients with AF recurrence had larger atrial surfaces and longer total RCAAF times. Both the pre-ablation hs-CRP level and 1-day post-RCAAF NT-proBNP level were significantly associated with an increased risk of recurrence.
CONCLUSIONS
The pre-ablation hs-CRP level and immediate post-ablation NT-proBNP level were markers for atrial arrhythmia recurrence after RCAAF. This confirms growing evidence of the role of inflammation in the pathogenesis of AF. These biomarkers appear to be promising stratification tools for selection and management of patients undergoing RCAAF.
- Language
-
- English
- Open access status
- gold
- Identifiers
-
- DOI 10.1177/0300060518793807
- PMID 30178684
- Persistent URL
- https://folia.unifr.ch/global/documents/109998
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