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Human Milk Oligosaccharides in the Milk of Mothers Delivering Term versus Preterm Infants.

  • Austin S Nestlé Research, Vers-Chez-Les-Blanc, 1000 Lausanne, Switzerland. sean.austin@rdls.nestle.com.
  • De Castro CA Nestle Research Singapore, 29 Quality Road, 618802 Singapore, Singapore. norbert.sprenger@rdls.nestle.com.
  • Sprenger N Nestlé Research, Vers-Chez-Les-Blanc, 1000 Lausanne, Switzerland. Aristea.Binia@rdls.nestle.com.
  • Binia A Nestlé Research, Vers-Chez-Les-Blanc, 1000 Lausanne, Switzerland. michael.affolter@rdls.nestle.com.
  • Affolter M Nestlé Research, Vers-Chez-Les-Blanc, 1000 Lausanne, Switzerland. Clara.Garcia@rdls.nestle.com.
  • Garcia-Rodenas CL Nestlé Research, Vers-Chez-Les-Blanc, 1000 Lausanne, Switzerland. CarlosAntonio.DeCastro@rdsg.nestle.com.
  • Beauport L Centre Hospitalier Universitaire Vaudois, 1011 Lausanne, Switzerland. Lydie.Beauport@chuv.ch.
  • Tolsa JF Centre Hospitalier Universitaire Vaudois, 1011 Lausanne, Switzerland. Jean-Francois.Tolsa@chuv.ch.
  • Fischer Fumeaux CJ Centre Hospitalier Universitaire Vaudois, 1011 Lausanne, Switzerland. Celine-Julie.Fischer@chuv.ch.
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  • 2019-06-15
Published in:
  • Nutrients. - 2019
2′-fucosyllactose (2′FL)
3′-sialyllactose (3′SL)
Lewis
disialyllacto-N-tetraose (DSLNT)
human milk oligosaccharides (HMO)
lactation
milk group
preterm
secretor
Adult
Birth Weight
Breast Feeding
Female
Gestational Age
Humans
Infant
Infant, Newborn
Infant, Premature
Infant, Very Low Birth Weight
Lactation
Milk, Human
Oligosaccharides
Postpartum Period
Pregnancy
Prospective Studies
Term Birth
English Human milk oligosaccharides (HMOs) are a major component of human milk, and play an important role in protecting the infant from infections. Preterm infants are particularly vulnerable, but have improved outcomes if fed with human milk. This study aimed to determine if the HMO composition of preterm milk differed from that of term milk at equivalent stage of lactation and equivalent postmenstrual age. In all, 22 HMOs were analyzed in 500 samples of milk from 25 mothers breastfeeding very preterm infants (< 32 weeks of gestational age, < 1500g of birthweight) and 28 mothers breastfeeding term infants. The concentrations of most HMOs were comparable at equivalent postpartum age. However, HMOs containing α-1,2-linked fucose were reduced in concentration in preterm milk during the first month of lactation. The concentrations of a number of sialylated oligosaccharides were also different in preterm milk, in particular 3'-sialyllactose concentrations were elevated. At equivalent postmenstrual age, the concentrations of a number of HMOs were significantly different in preterm compared to term milk. The largest differences manifest around 40 weeks of postmenstrual age, when the milk of term infants contains the highest concentrations of HMOs. The observed differences warrant further investigation in view of their potential clinical impact.
Language
  • English
Open access status
gold
Identifiers
Persistent URL
https://folia.unifr.ch/global/documents/106635
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