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Self-assembled thermoresponsive nanostructures of hyaluronic acid conjugates for osteoarthritis therapy.
Journal article

Self-assembled thermoresponsive nanostructures of hyaluronic acid conjugates for osteoarthritis therapy.

  • Maudens P School of Pharmaceutical Sciences, University of Geneva, University of Lausanne, CH-1211 Geneva 4, Switzerland. Eric.Allemann@unige.ch.
  • Meyer S School of Pharmaceutical Sciences, University of Geneva, University of Lausanne, CH-1211 Geneva 4, Switzerland. Eric.Allemann@unige.ch.
  • Seemayer CA Department of Clinical Science, Idorsia Pharmaceuticals Ltd., CH-4123 Allschwil, Switzerland.
  • Jordan O School of Pharmaceutical Sciences, University of Geneva, University of Lausanne, CH-1211 Geneva 4, Switzerland. Eric.Allemann@unige.ch.
  • Allémann E School of Pharmaceutical Sciences, University of Geneva, University of Lausanne, CH-1211 Geneva 4, Switzerland. Eric.Allemann@unige.ch.
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  • 2018-01-09
Published in:
  • Nanoscale. - 2018
Animals
Cartilage
Cells, Cultured
Drug Carriers
Fibroblasts
Humans
Hyaluronic Acid
Injections, Intra-Articular
Male
Mice
Mice, Inbred C57BL
Nanostructures
Osteoarthritis
Synovial Membrane
English Under pathological conditions, joints and skin are often affected by an imbalance in the breakdown and production of hyaluronic acid (HA). The unique biochemical and biomechanical properties provided by HA must be restored for the long-term lubrication and cushioning effects. To overcome the inconvenience of repeated injections and the rapid degradation of exogenous HA treatments, HA is conjugated to a thermosensitive polymer, enabling the spontaneous formation of nanoparticles (HA Nano) at body temperature. Three HA Nano preparations are tested for their injectability, sensitivity to enzymatic degradation and cytocompatibility. One of them is delivered via subcutaneous and intra-articular injections to healthy mice and tested in a murine osteoarthritis (OA) model. It is found to be biocompatible, to offer a prolonged residence time at the injection site, have the ability to protect cartilage, to reduce pro-inflammatory cytokines and to preserve epiphysis thickness. In this study, HA Nano spontaneously forms nanoparticles at body temperature in vivo and is a promising candidate for the next generation of the sustainable/long-lasting treatment of OA and potentially also dermatological conditions.
Language
  • English
Open access status
hybrid
Identifiers
Persistent URL
https://folia.unifr.ch/global/documents/103398
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