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Amide synthesis via nickel-catalysed reductive aminocarbonylation of aryl halides with nitroarenes.
Journal article

Amide synthesis via nickel-catalysed reductive aminocarbonylation of aryl halides with nitroarenes.

  • Cheung CW Laboratory of Inorganic Synthesis and Catalysis , Institute of Chemical Sciences and Engineering , Ecole Polytechnique Fédérale de Lausanne (EPFL) , ISIC-LSCI , BCH 3305 , Lausanne 1015 , Switzerland . Email: xile.hu@epfl.ch ; http://lsci.epfl.ch.
  • Leendert Ploeger M Laboratory of Inorganic Synthesis and Catalysis , Institute of Chemical Sciences and Engineering , Ecole Polytechnique Fédérale de Lausanne (EPFL) , ISIC-LSCI , BCH 3305 , Lausanne 1015 , Switzerland . Email: xile.hu@epfl.ch ; http://lsci.epfl.ch.
  • Hu X Laboratory of Inorganic Synthesis and Catalysis , Institute of Chemical Sciences and Engineering , Ecole Polytechnique Fédérale de Lausanne (EPFL) , ISIC-LSCI , BCH 3305 , Lausanne 1015 , Switzerland . Email: xile.hu@epfl.ch ; http://lsci.epfl.ch.
  • 2018-04-10
Published in:
  • Chemical science. - 2018
English Aminocarbonylation of aryl halides is one of the most useful methods in amide synthesis, but nitroarenes have not been used as a nitrogen source in this method even though they are more economical and accessible than anilines. Reported here is the development of nickel catalysis for the first three-component reactions of aryl halides, Co2(CO)8, and nitroarenes under reductive conditions to produce aryl amides. A wide range of (hetero)aryl iodides and bromides as well as nitro(hetero)arenes are suitable reaction partners, and high functional group compatibility has been achieved. The method might be used for the streamlined synthesis of aryl amides.
Language
  • English
Open access status
gold
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Persistent URL
https://folia.unifr.ch/global/documents/10336
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