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Chickenpox is not always benign: postvaricella purpura fulminans requires prompt and aggressive treatment.
Journal article

Chickenpox is not always benign: postvaricella purpura fulminans requires prompt and aggressive treatment.

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  • 2010-12-07
Published in:
  • Pediatric emergency care. - 2010
Antigens, Viral
Autoimmune Diseases
Chickenpox
Child, Preschool
Combined Modality Therapy
Diagnosis, Differential
Disseminated Intravascular Coagulation
Female
Herpes Zoster
Humans
Immunoglobulins, Intravenous
Male
Models, Immunological
Molecular Mimicry
Plasma
Prednisone
Protein S
Protein S Deficiency
Purpura Fulminans
English We present 2 patients, who were admitted owing to rapidly progressing purpuric lesions due to postvaricella purpura fulminans, a coagulopathy leading to life- or limb-threatening thrombosis caused by a severe transient autoimmune protein S deficiency. Laboratory results were being consistent with disseminated intravascular coagulation secondary to protein S deficiency; treatment with fresh frozen plasma, intravenous immunoglobulins, and prednisone was started. In our experience, a prompt therapy may limit the course and the extent of the disease. We present a review of the topic with supporting literature for the therapeutic options. Therefore, we should be reminded that purpura fulminans is a rare but severe complication of chickenpox, which demands quick action.
Language
  • English
Open access status
closed
Identifiers
Persistent URL
https://folia.unifr.ch/global/documents/101548
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