Back
Full-text
Journal article

Material Tissue Interaction—From Toxicity to Tissue Regeneration

  • Schmalz, G Gottfried Schmalz, DDS, PhD, University of Bern, Department of Preventive, Restorative and Pediatric Dentistry, Freiburgstrasse 7, CH-3010 Bern, Switzerland; University Hospital Regensburg, Department of Conservative Dentistry and Periodontology, Franz-Josef-Strauß-Allee 11, D-93053, Regensburg, Germany
  • Widbiller, M Matthias Widbiller, DDS, University Hospital Regensburg, Department of Conservative Dentistry and Periodontology, Regensburg, Germany
  • Galler, KM Kerstin M Galler, DDS, PhD, University Hospital Regensburg, Department of Conservative Dentistry and Periodontology, Regensburg, Germany
Published in:
  • Operative Dentistry. - Operative Dentistry. - 2016, vol. 41, no. 2, p. 117-131
General Dentistry
English SUMMARY
The topic of material tissue interaction has gained increasing interest over recent decades from both the dental profession and the public. The primary goal initially was to avoid adverse reactions after the application of dental materials. New laboratory test methods have been developed, and currently premarket testing programs, which attempt to guarantee a basic level of patient safety, are legally required worldwide. The dentist is responsible for selecting the correct indication as well as the proper handling of any newly emerging risk. Apart from this phenomenon-oriented “inert materials concept,” the “analytical concept” focuses primarily on analyzing the reasons for adverse reactions, and identifying their associated modifying factors, in order to prevent them or to develop new and more biocompatible materials. The “concept of bioactivity” involves addressing the possibility of positively influencing tissue by materials application, such as the generation of tertiary dentin or antibacterial effects. Finally, tissue regeneration may be supported and promoted by the use of various suitable materials (matrices/scaffolds) into which stem cells can migrate or be seeded, leading to cell differentiation and the generation of new tissue. These new dental materials must also fulfill additional requirements such as controlled degradability in order to be suitable for clinical use. Clearly, the field of material tissue interaction is complex and comprises a wide range of issues. To be successful as dentists in the future, practitioners should remain informed of these important new developments and have the argumentative competence to both properly advise and treat their patients.
Language
  • English
Open access status
bronze
Identifiers
Persistent URL
https://folia.unifr.ch/global/documents/10070
Statistics
Document views: 10 File downloads:
  • fulltext.pdf: 0