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Biocompatible Polymer Nanoformulation To Improve the Release and Safety of a Drug Mimic Molecule Detectable via ICP-MS.
Journal article

Biocompatible Polymer Nanoformulation To Improve the Release and Safety of a Drug Mimic Molecule Detectable via ICP-MS.

  • Ferrari R Institute for Chemical and Bioengineering, Department of Chemistry and Applied Biosciences, ETH Zurich , Vladimir-Prelog-Weg 1, 8093 Zurich, Switzerland.
  • Talamini L Department of Molecular Biochemistry and Pharmacology, IRCCS - Istituto di Ricerche Farmacologiche Mario Negri , Via La Masa 19, 20156 Milan, Italy.
  • Violatto MB Department of Molecular Biochemistry and Pharmacology, IRCCS - Istituto di Ricerche Farmacologiche Mario Negri , Via La Masa 19, 20156 Milan, Italy.
  • Giangregorio P Department of Molecular Biochemistry and Pharmacology, IRCCS - Istituto di Ricerche Farmacologiche Mario Negri , Via La Masa 19, 20156 Milan, Italy.
  • Sponchioni M Department of Chemistry, Materials and Chemical Engineering, Politecnico di Milano , Via Mancinelli 7, 20131 Milan, Italy.
  • Morbidelli M Institute for Chemical and Bioengineering, Department of Chemistry and Applied Biosciences, ETH Zurich , Vladimir-Prelog-Weg 1, 8093 Zurich, Switzerland.
  • Salmona M Department of Molecular Biochemistry and Pharmacology, IRCCS - Istituto di Ricerche Farmacologiche Mario Negri , Via La Masa 19, 20156 Milan, Italy.
  • Bigini P Department of Molecular Biochemistry and Pharmacology, IRCCS - Istituto di Ricerche Farmacologiche Mario Negri , Via La Masa 19, 20156 Milan, Italy.
  • Moscatelli D Department of Chemistry, Materials and Chemical Engineering, Politecnico di Milano , Via Mancinelli 7, 20131 Milan, Italy.
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  • 2016-12-13
Published in:
  • Molecular pharmaceutics. - 2017
ICP-MS
biodistribution
drug delivery
drug development
nanoparticle
titanium
Animals
Antineoplastic Agents
Biocompatible Materials
Chemistry, Pharmaceutical
Drug Carriers
Drug Delivery Systems
Male
Mice
Microscopy, Electron, Transmission
Nanoparticles
Organometallic Compounds
Polyesters
Polymers
Titanium
English Fluorescent poly(ε-caprolactone)-based nanoparticles (NPs) have been synthesized and successfully loaded with a titanium organometallic compound as a mimic of a water-insoluble drug. The nature of this nanovector enabled us to combine the quantification of the metal in tissues after systemic administration in healthy immunocompetent mice by inductively coupled plasma mass spectroscopy (ICP-MS) followed by the visualization of NPs in organ sections by confocal microscopy. This innovative method of nanodrug screening has enabled us to elucidate the crucial parameters of their kinetics. The organometallic compound is a good mimic of most anticancer drugs, and this approach is an interesting starting point to design the relevance of a broad range of nanoformulations in terms of safety and targeted delivery of the cargoes.
Language
  • English
Open access status
closed
Identifiers
Persistent URL
https://folia.unifr.ch/global/documents/65756
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