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Hypoglycemia-activated GLUT2 neurons of the nucleus tractus solitarius stimulate vagal activity and glucagon secretion

Université de Fribourg

  • Lamy, Christophe M. Department of Fundamental Neurosciences, University of Lausanne, Switzerland - Department of Medicine, University of Fribourg, Switzerland
  • Sanno, Hitomi Center for Integrative Genomics, University of Lausanne, Switzerland
  • Labouèbe, Gwenaël Center for Integrative Genomics, University of Lausanne, Switzerland
  • Picard, Alexandre Center for Integrative Genomics, University of Lausanne, Switzerland
  • Magnan, Christophe CNRS-University Paris Diderot, Paris, France
  • Chatton, Jean-Yves Department of Fundamental Neurosciences, University of Lausanne, Switzerland
  • Thorens, Bernard Center for Integrative Genomics, University of Lausanne, Switzerland
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    04.03.2014
Published in:
  • Cell Metabolism, 2014, vol. 19, no. 3, p. 527–538
English Glucose-sensing neurons in the brainstem participate in the regulation of energy homeostasis but have been poorly characterized because of the lack of specific markers to identify them. Here we show that GLUT2-expressing neurons of the nucleus of the tractus solitarius form a distinct population of hypoglycemia-activated neurons. Their response to low glucose is mediated by reduced... Show more…
Language
  • English
Identifiers
Classification
Biology
Faculty
Faculté des sciences
Department
Médecine
License
License undefined
Persistent URL
https://folia.unifr.ch/global/documents/303694
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