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Multidrug-resistant Acinetobacter baumannii strains carrying the blaOxA-23 and the blaGES-11 genes in a neonatology center in Tunisia

Université de Fribourg

  • Charfi-Kessis, Karama INSERM U914, South-Paris Medical School, K.-Bicêtre, France - Laboratoire des Maladies Transmissibles et Substances Biologiquement Actives LR99ES27, Faculté de Pharmacie, Monastir, Tunisia
  • Mansour, Wejdene Laboratoire des Maladies Transmissibles et Substances Biologiquement Actives LR99ES27, Faculté de Pharmacie, Monastir, Tunisia
  • Khalifa, Anis Ben Haj Laboratoire de Microbiologie, CHU Taher Sfar Mahdia, Tunisia
  • Mastouri, Maha Laboratoire des Maladies Transmissibles et Substances Biologiquement Actives LR99ES27, Faculté de Pharmacie, Monastir, Tunisia
  • Nordmann, Patrice INSERM U914, South-Paris Medical School, K.-Bicêtre, France - Medical and Molecular Microbiology Unit, Department of Medicine, Faculty of Science, University of Fribourg, Switzerland
  • Aouni, Mahjoub Laboratoire des Maladies Transmissibles et Substances Biologiquement Actives LR99ES27, Faculté de Pharmacie, Monastir, Tunisia
  • Poirel, Laurent INSERM U914, South-Paris Medical School, K.-Bicêtre, France - Medical and Molecular Microbiology Unit, Department of Medicine, Faculty of Science, University of Fribourg, Switzerland
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    22.07.2014
Published in:
  • Microbial Pathogenesis. - 2014, vol. 74, p. 20–24
Acinetobacter baumannii
GES 11
OXA 23
Carbapenem resistance
Neonatology center
Tunisia
English Multidrug-resistant and difficult-to-treat Acinetobacter baumannii may be responsible for nosocomial infections. The production of carbapenem-hydrolyzing class D β-lactamases (CHDLs) and extended-spectrum β-lactamase (ESBLs) of the GES type possessing a carbapenemase activity has been increasingly reported worldwide in A. baumannii. The aim of this study was to analyze the resistance mechanisms of two carbapenem resistant A. baumannii clinical isolates recovered in a neonatology center in the center-east of Tunisia.Two carbapenem resistant A. baumannii isolates were recovered. The first isolate co-harbored the blaGES-11 ESBL gene and the blaOxA-23 CHDL gene. Analyses of the genetic location indicated that the blaGES-11 gene was plasmid located (Gr6). However, the blaOxA-23 gene was located on the chromosome. The second strain had only the blaOxA-23 CHDL gene, which was plasmid located.This study showed the first description of the GES-type β-lactamase in A. baumannii in Tunisia.
Faculty
Faculté des sciences et de médecine
Department
Médecine 3ème année
Language
  • English
Classification
Biological sciences
License
License undefined
Identifiers
Persistent URL
https://folia.unifr.ch/global/documents/303675
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