SnapShot: ADP-Ribosylation Signaling.
- Hottiger MO Institute of Veterinary Biochemistry and Molecular Biology, University of Zurich, 8057 Zurich, Switzerland.
- 2015-06-20
Published in:
- Molecular cell. - 2015
ADP Ribose Transferases
Adenosine Diphosphate Ribose
Biosynthetic Pathways
Humans
Models, Chemical
Molecular Structure
NAD
Niacinamide
Poly (ADP-Ribose) Polymerase-1
Poly Adenosine Diphosphate Ribose
Poly(ADP-ribose) Polymerases
Signal Transduction
English
Intracellular protein ADP-ribosylation is catalyzed by diphteria toxin-like ADP-ribosyltransferases (ARTDs, formerly PARPs) ("writers"), which use NAD(+) for the modification of different amino acids. While some ARTD members catalyze protein poly-ADP-ribosylation, most of them are mono-ADP-ribosyltransferases. ADP-ribosylation is recognized by protein domains ("readers") and reversed by different enzymes ("erasers"). ADP-ribosylation signaling regulates several key cellular processes during health and disease.
- Language
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- English
- Open access status
- bronze
- Identifiers
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- DOI 10.1016/j.molcel.2015.06.001
- PMID 26091348
- Persistent URL
- https://folia.unifr.ch/global/documents/255499
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