Racial Differences in Cancer Susceptibility and Survival: More Than the Color of the Skin?
- Özdemir BC Department of Oncology, Centre Hospitalier Universitaire Vaudois, Rue du Bugnon 46, 1011 Lausanne, Switzerland.
- Dotto GP Department of Biochemistry, University of Lausanne, Chemin des Boveresses 155, 1066 Épalinges, Switzerland; Harvard Dermatology Department and Cutaneous Biology Research Center, Massachusetts General Hospital, 55 Fruit Street, Boston, MA 02129, USA. Electronic address: paolo.dotto@unil.ch.
- 2017-07-19
Published in:
- Trends in cancer. - 2017
Asian Americans
Continental Population Groups
European Continental Ancestry Group
Genetic Predisposition to Disease
Healthcare Disparities
Hispanic Americans
Humans
Neoplasms
Social Class
English
Epidemiological studies point to race as a determining factor in cancer susceptibility. In US registries recording cancer incidence and survival by race (distinguishing 'black versus white'), individuals of African ancestry have a globally increased risk of malignancies compared with Caucasians and Asian Americans. Differences in socioeconomic status and health-care access play a key role. However, the lesser disease susceptibility of Hispanic populations with comparable lifestyles and socioeconomic status as African Americans (Hispanic paradox) points to the concomitant importance of genetic determinants. Here, we overview the molecular basis of racial disparity in cancer susceptibility ranging from genetic polymorphisms and cancer-driver gene mutations to obesity, chronic inflammation, and immune responses. We discuss implications for race-adapted cancer screening programs and clinical trials to reduce disparities in cancer burden.
- Language
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- English
- Open access status
- green
- Identifiers
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- DOI 10.1016/j.trecan.2017.02.002
- PMID 28718431
- Persistent URL
- https://folia.unifr.ch/global/documents/181550
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