"Supplemental Table S4: Proteins in cluster 4 were tested for significantly enriched terms (p<0.05, BH corrected). Minimum number of 5 proteins carrying respective terms." Cluster ID Type Name P value Enrichment Total In cluster Cluster size Benj. Hoch. FDR 4 GOCC name acrosomal vesicle 0.0027368 3.2401 5 5 304 0.036126 4 GOBP name actin filament-based movement 5.43E-05 2.9456 11 10 304 0.0039363 4 GOCC name adherens junction 0.00125 1.8107 34 19 304 0.022297 4 KEGG name Amoebiasis 0.0012246 2.1061 20 13 304 0.023063 4 GOBP name anatomical structure development 0.0006167 1.3631 145 61 304 0.022007 4 GOBP name anatomical structure formation involved in morphogenesis 0.00069549 1.6495 55 28 304 0.023723 4 GOCC name anchoring junction 0.00125 1.8107 34 19 304 0.02171 4 KEGG name Arrhythmogenic right ventricular cardiomyopathy (ARVC) 6.04E-07 2.7541 20 17 304 0.00013649 4 GOBP name biological adhesion 5.08E-07 1.906 68 40 304 9.82E-05 4 Keywords Calcium 2.96E-05 1.6596 82 42 304 0.00066766 4 GOMF name carbohydrate binding 0.0010642 1.6905 46 24 304 0.035738 4 GOMF name cation binding 0.0011036 1.2764 198 78 304 0.036061 4 GOBP name cell adhesion 5.08E-07 1.906 68 40 304 9.43E-05 4 GOBP name cell junction assembly 1.69E-05 2.2346 29 20 304 0.0016303 4 GOBP name cell junction organization 3.56E-05 2.1601 30 20 304 0.0027969 4 GOBP name cell migration 0.00091461 1.5935 61 30 304 0.028863 4 GOCC name cell projection 0.0014447 1.4217 98 43 304 0.023256 4 GOBP name cell redox homeostasis 0.00026482 2.5458 14 11 304 0.011168 4 GOCC name cell surface 0.00025793 1.8001 45 25 304 0.0056744 4 Keywords Celladhesion 8.09E-07 2.1355 44 29 304 3.04E-05 4 GOBP name cell-cell adhesion 0.00066338 2.2872 17 12 304 0.022796 4 GOBP name cell-matrix adhesion 0.00027927 2.4301 16 12 304 0.011567 4 Keywords Cellmembrane 0.0039763 1.301 132 53 304 0.030919 4 GOBP name cell-substrate adhesion 4.53E-05 2.4301 20 15 304 0.0034447 4 GOBP name cellular homeostasis 0.00038495 1.6466 61 31 304 0.014638 4 Keywords Cleavageonpairofbasicresidues 0.0044345 2.5201 9 7 304 0.033898 4 GOBP name collagen fibril organization 5.43E-05 2.9456 11 10 304 0.0038758 4 GOCC name cytoplasmic membrane-bounded vesicle 0.0020623 1.4132 94 41 304 0.02896 4 GOBP name developmental process 0.00021332 1.2668 266 104 304 0.0096077 4 KEGG name Dilated cardiomyopathy 0.00011316 2.3875 19 14 304 0.0036534 4 Keywords Dioxygenase 7.72E-05 3.2401 8 8 304 0.0012893 4 GOMF name dioxygenase activity 7.72E-05 3.2401 8 8 304 0.0077765 4 GOMF name disulfide oxidoreductase activity 0.0006879 2.4924 13 10 304 0.033267 4 Keywords Disulfidebond 5.03E-12 1.8447 137 78 304 3.24E-10 4 Keywords Dwarfism 0.0044345 2.5201 9 7 304 0.033333 4 KEGG name ECM-receptor interaction 0.00049177 2.1131 23 15 304 0.011114 4 Keywords Ehlers-Danlossyndrome 0.0027368 3.2401 5 5 304 0.022442 4 GOCC name endoplasmic reticulum 7.14E-07 1.7957 83 46 304 3.92E-05 4 GOCC name endoplasmic reticulum lumen 1.35E-15 2.8634 43 38 304 8.90E-13 4 GOCC name endoplasmic reticulum membrane 8.69E-06 1.7844 69 38 304 0.00035862 4 GOCC name endoplasmic reticulum part 9.83E-14 1.9757 123 75 304 1.62E-11 4 Keywords Endoplasmicreticulum 2.99E-12 1.9075 124 73 304 2.24E-10 4 GOCC name external side of plasma membrane 0.0015486 2.2276 16 11 304 0.024336 4 GOBP name extracellular matrix organization 5.08E-09 2.3244 46 33 304 1.96E-06 4 GOCC name extracellular region part 0.00029236 1.4701 108 49 304 0.0060299 4 GOCC name extracellular space 0.0018357 1.5642 58 28 304 0.026923 4 GOBP name extracellular structure organization 5.08E-09 2.3244 46 33 304 1.81E-06 4 Keywords Extracellularmatrix 0.00037422 2.0401 27 17 304 0.0048221 4 KEGG name Focal adhesion 0.0012541 1.6531 49 25 304 0.021802 4 GOMF name GDP binding 0.0006879 2.4924 13 10 304 0.031987 4 GOBP name glycolipid metabolic process 0.00025417 3.2401 7 7 304 0.01102 4 Keywords Glycoprotein 9.86E-18 1.8563 192 110 304 1.48E-15 4 Keywords Glycosidase 0.00025417 3.2401 7 7 304 0.0036978 4 GOBP name glycosphingolipid metabolic process 0.00025417 3.2401 7 7 304 0.010918 4 Keywords Hydrogeniontransport 0.0016868 2.5921 10 8 304 0.016186 4 GOMF name "hydrolase activity, hydrolyzing O-glycosyl compounds" 0.00016317 2.9161 10 9 304 0.011604 4 KEGG name Hypertrophic cardiomyopathy (HCM) 0.00011005 2.4777 17 13 304 0.0049742 4 GOCC name integral to membrane 0.00028722 1.3532 170 71 304 0.0061151 4 Keywords Integrin 0.0014159 2.8351 8 7 304 0.01419 4 GOMF name integrin binding 0.00083501 3.2401 6 6 304 0.028844 4 GOCC name integrin complex 0.0014159 2.8351 8 7 304 0.023961 4 GOCC name intracellular organelle lumen 7.39E-13 2.003 110 68 304 8.13E-11 4 GOMF name "intramolecular oxidoreductase activity, interconverting keto- and enol-groups" 2.34E-05 3.2401 9 9 304 0.0047121 4 GOMF name "intramolecular oxidoreductase activity, transposing S-S bonds" 2.34E-05 3.2401 9 9 304 0.0040389 4 GOCC name intrinsic to membrane 5.92E-05 1.3912 177 76 304 0.0016976 4 GOMF name ion binding 0.0011036 1.2764 198 78 304 0.035112 4 GOMF name isomerase activity 0.00078458 1.9939 26 16 304 0.033877 4 GOMF name L-ascorbic acid binding 0.00025417 3.2401 7 7 304 0.015365 4 Keywords Lectin 0.0006259 2.651 11 9 304 0.0074284 4 KEGG name Leukocyte transendothelial migration 0.00011106 2.3144 21 15 304 0.0041831 4 GOCC name lysosomal lumen 4.53E-05 2.4301 20 15 304 0.0016608 4 Keywords Lysosome 2.99E-06 2.2994 31 22 304 8.99E-05 4 KEGG name Lysosome 8.88E-05 2.1601 27 18 304 0.0050166 4 GOCC name lysosome 0.001065 2.0619 22 14 304 0.020083 4 GOCC name lytic vacuole 0.001065 2.0619 22 14 304 0.019525 4 Keywords Membrane 6.82E-08 1.3525 333 139 304 2.79E-06 4 GOCC name membrane 9.70E-07 1.2908 369 147 304 4.92E-05 4 GOCC name membrane part 1.88E-08 1.3871 313 134 304 1.13E-06 4 GOCC name membrane-bounded vesicle 6.54E-05 1.4797 127 58 304 0.0017998 4 GOCC name membrane-enclosed lumen 4.14E-13 1.9493 123 74 304 5.47E-11 4 GOMF name metal ion binding 0.0012906 1.2729 196 77 304 0.037151 4 Keywords Metal-binding 0.00081779 1.333 158 65 304 0.0092206 4 GOBP name multicellular organismal process 0.00025128 1.3797 155 66 304 0.010997 4 GOBP name muscle cell differentiation 0.00016317 2.9161 10 9 304 0.0095815 4 Keywords Muscleprotein 0.0014159 2.8351 8 7 304 0.013882 4 Keywords Myosin 7.72E-05 3.2401 8 8 304 0.0012433 4 GOCC name myosin complex 7.72E-05 3.2401 8 8 304 0.0020377 4 GOCC name organelle lumen 8.70E-15 2.0493 117 74 304 2.87E-12 4 GOCC name organelle membrane 0.0017581 1.2601 198 77 304 0.026986 4 Keywords Osteogenesisimperfecta 7.72E-05 3.2401 8 8 304 0.0012004 4 Keywords Oxidoreductase 0.001986 1.5027 69 32 304 0.017914 4 GOMF name oxidoreductase activity 0.00023984 1.5311 91 43 304 0.015262 4 GOMF name "oxidoreductase activity, acting on a sulfur group of donors" 4.25E-05 2.5201 18 14 304 0.0051425 4 GOMF name "oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen, 2-oxoglutarate as one donor, and incorporation of one atom each of oxygen into both donors" 2.34E-05 3.2401 9 9 304 0.0035341 4 GOMF name "oxidoreductase activity, acting on single donors with incorporation of molecular oxygen" 7.72E-05 3.2401 8 8 304 0.0071784 4 GOMF name "oxidoreductase activity, acting on single donors with incorporation of molecular oxygen, incorporation of two atoms of oxygen" 7.72E-05 3.2401 8 8 304 0.0066656 4 GOBP name peptidyl-amino acid modification 0.00039729 1.7609 46 25 304 0.014984 4 GOBP name peptidyl-proline modification 0.00048421 2.8801 9 8 304 0.017687 4 GOCC name plasma membrane 9.50E-05 1.3708 182 77 304 0.002411 4 GOCC name plasma membrane part 0.0018104 1.3234 142 58 304 0.027157 4 GOMF name protein complex binding 0.0012246 2.1061 20 13 304 0.037012 4 GOMF name protein disulfide isomerase activity 2.34E-05 3.2401 9 9 304 0.0031414 4 GOMF name protein disulfide oxidoreductase activity 5.43E-05 2.9456 11 10 304 0.0059687 4 KEGG name Protein processing in endoplasmic reticulum 0.00071887 1.6849 50 26 304 0.01477 4 GOCC name proton-transporting two-sector ATPase complex 0.00025417 3.2401 7 7 304 0.0057846 4 GOCC name "proton-transporting two-sector ATPase complex, catalytic domain" 0.0027368 3.2401 5 5 304 0.035418 4 Keywords Pyrrolidonecarboxylicacid 0.0016868 2.5921 10 8 304 0.015849 4 GOMF name receptor binding 0.00049084 1.7193 49 26 304 0.025801 4 Keywords Redox-activecenter 0.00027708 2.3401 18 13 304 0.0036753 4 GOBP name regulation of biological quality 0.00057131 1.2961 200 80 304 0.020545 4 Keywords Secreted 3.59E-05 1.7821 60 33 304 0.00077123 4 GOBP name secretion by cell 0.00065555 1.8515 35 20 304 0.022695 4 GOMF name serine hydrolase activity 0.00048421 2.8801 9 8 304 0.027877 4 GOMF name serine-type peptidase activity 0.00048421 2.8801 9 8 304 0.02661 4 Keywords Signal 1.18E-29 2.2372 168 116 304 5.31E-27 4 Keywords Signal-anchor 0.00043109 2.0737 25 16 304 0.0052546 4 KEGG name Tight junction 0.00026396 2.2681 20 14 304 0.0074569 4 Keywords Transmembrane 2.19E-05 1.4295 170 75 304 0.00051957 4 Keywords Transmembranehelix 4.18E-05 1.4163 167 73 304 0.00085711 4 GOCC name vacuolar lumen 4.53E-05 2.4301 20 15 304 0.0015734 4 GOCC name vacuolar part 4.65E-05 2.0141 37 23 304 0.0015331 4 GOCC name vacuole 0.0019021 1.9723 23 14 304 0.027291 4 GOBP name vacuole organization 0.00083501 3.2401 6 6 304 0.026532 4 GOCC name vesicle 0.00025234 1.4088 138 60 304 0.0059481 4 GOCC name vesicle lumen 0.0014159 2.8351 8 7 304 0.023362 4 Keywords VitaminC 0.00025417 3.2401 7 7 304 0.0035822 4 Keywords Zymogen 0.00026482 2.5458 14 11 304 0.0036191