"*""M"" only has the Mtases protein;""R+M"" has the Mtases protein and Reases protein" 217 completely sequenced K. pneumoniae strains used in this study R-M systems Type I Type II* Type III* Type IV ID Strains blaKPC Clonal Grpop MLST RM in chromosome(clades) RM in plasmids (clades) 29 K. pneumoniae ATCC BAA-2146 CG258 11 M+R 30 K. pneumoniae HS11286 CP003224.1 CG258 11 clade7 M 31 K. pneumoniae JM45 CP006657.1 CG258 11 M 32 K. pneumoniae CAV1392 CP011575.1 CG258 11 M 73 K. pneumoniae F 44 CP025463.1 CG258 11 M 74 K. pneumoniae JS187 CP025468.1 CG258 11 "clade6,7" M 94 KP38731 CG258 11 clade 2 M 125 Kp_Goe_822917 CG258 11 M 128 SWU01 NZ_CP018455.1 CG258 11 M 131 Kp_Goe_821588 CG258 11 M 138 AR_0049 CG258 11 M+R M+R 152 K66-45 CG258 11 "clade4,6" M 155 AR_0146 CG258 11 "clade6,18" M 166 AR_0148 CG258 11 clade6 M M+R 171 911021 CG258 11 M 172 721005 CG258 11 M 179 FDAARGOS_443 CP023938.1 (unnamed 2) CG258 11 clade6 M 180 FDAARGOS_444 CP023942.1 CG258 11 M 208 GD4 CP025952.1 CG258 11 M 213 WCHKP649 CP026584.1 CG258 11 M 216 WCHKP8F4 CP027067.1 CG258 11 M 93 FDAARGOS_156 13 "clade 2,13" M 1 K. pneumoniae PittNDM01 14 "clade3,9" clade6 M 2 K. pneumoniae KP617 14 "clade3,9" M 3 K. pneumoniae U25 14 M 90 NUHL24835 14 M 113 K.pneumoniae 11 14 114 K.pneumoniae 23 14 145 AR_0068 14 "clade3,8" clade4 M 151 KPN528 14 "clade3,8" M 157 AR_0143 14 "clade3,8" "clade6,9" M 215 AR_0066 14 "clade3,8" M 4 K. pneumoniae PMK1 15 clade8 "clade4,7" M 108 BR CP015991.1 15 "clade3,8" M 115 KP36 15 "clade3,8" clade4 M 129 Kp_Goe_39795 15 "clade3,8" M 169 19051 15 clade8 M 170 DHQP1605752_NV 15 57 K. pneumoniae QS17-0029  16 clade5 "clade29,4" M 85 UCLAOXA232KP_Pt0 16 M 86 UCLAOXA232KP 16 clade6 M 177 FDAARGOS_440 16 "clade5,29" clade4 M 5 K. pneumoniae XH209 17 "clade5,15" M 6 K. pneumoniae NTUH-K2044 23 M 7 K. pneumoniae 1084 23 M M+R 76 K. pneumoniae KP1 23 77 K. pneumoniae KP6 23 M 80 K. pneumoniae KP9 23 M 92 RJF999 23 M 111 ED2 23 M M+R 112 ED23 23 M 117 P1428 23 M M+R 121 Kp_Goe_154414 23 clade1 141 RJA166 23 clade4 M 202 SGH10 23 clade28 M 219 KPHS1249 23 M 8 K. pneumoniae KP-1 29 clade13 M 81 K. pneumoniae KP10 29 M 83 K. pneumoniae KP14 29 clade22 M 186 INF322 29 M 187 INF249 29 M+R 33 K. pneumoniae KPNIH27 CP007732.1 34 clade6 M 110 DHQP1002001 34 clade8 clade4 M 206 HZW25 34 M 9 K. pneumoniae RYC492 35 clade26 71 K. pneumoniae KSB1_7J 37 M+R 97 KPNIH39 CP014765.1 37 clade12 clade4 M 120 459 37 M 149 KPN1482 37 "clade8,20,27" M 168 AR_0139 37 clade27 clade7 M 195 INF042 37 "clade2,12" M 196 INF059 37 "clade2,12" M 10 K. pneumoniae MGH 78578 38 clade4 M 65 K. pneumoniae CAV1016 CP017937.1 45 clade 2 M 159 AR_0126 CP021743.1 45 clade2 M 185 QS17-0161 45 clade2 clade6 M 11 K. pneumoniae 1158 65 clade10 M 12 K. pneumoniae Kp52.145 66 M 13 K. pneumoniae SB3432 67 M 14 K. pneumoniae CG43 86 clade11 M 15 K. pneumoniae KP5-1 86 clade5 M 16 K. pneumoniae HK787 86 clade11 M 99 kp757 86 clade11 M 214 NUHL30457 CP026589.1 86 clade11 M 126 Kp_Goe_33208 101 M 127 Kp_Goe_71070 101 M 137 Kp_Goe_121641 101 M 174 ST101:960186733 101 clade6 M 17 K. pneumoniae J1 111 clade19 M 18 K. pneumoniae 342 146 clade28 M 19 K. pneumoniae MS6671 147 clade1 M 84 KP5 147 "clade1,3,5" clade7 M 89 TGH13 147 "clade1,3" M 96 AATZP 147 "clade1,3,4,8" clade4 M 105 SKGH01 147 "clade1,2" M 116 825795-1 147 M 119 Kp_Goe_822579 147 "clade1,3" M 130 Kp_Goe_149473 147 "clade1,3" M 132 Kp_Goe_149832 147 "clade1,3" M 133 Kp_Goe_827024 147 "clade1,3" M 134 Kp_Goe_827026 147 "clade1,3" M 135 Kp_Goe_152021 147 "clade1,3" M 136 KP_Goe_828304 147 "clade1,3" M 161 AR_0138 147 "clade1,2" clade18 M 164 AR_0145 147 "clade1,3" clade4 M 165 AR_0152 147 "clade1,3" clade4 M 176 FDAARGOS_439 147 "clade1,3" clade4 M 178 FDAARGOS_442 CP023928.1 147 clade1 clade4 M 184 DA48896 147 clade18 M 197 CRKP-2297 147 "clade1,2" M 198 CRKP-1215 147 "clade1,2" M 207 002SK2 147 M 182 FDAARGOS_447 CP023952.1 152 clade2 M 156 AR_0158 163 clade16 clade7 M 144 AR_0117 NZ_CP020066.1 234 M 210 KPNIH50 CP026175.1 252 M M 212 KPNIH48 "CP026395.1,CP026394.1" 252 M 20 K. pneumoniae yzusk-4 CG258 258 M 34 K. pneumoniae KPR0928 CP008833.1 CG258 258 clade4 M 35 K. pneumoniae 30684/NJST258_2 CP006919.1 CG258 258 M M+R 36 K. pneumoniae KPNIH1 CP008830.1 CG258 258 clade4 M M+R 37 K. pneumoniae KPNIH10 CP007730.1 CG258 258 clade4 M M+R 38 K. pneumoniae 30660/NJST258_1 CP006926.1 CG258 258 M M+R 39 K. pneumoniae KPNIH24 CP008798.1 CG258 258 M M+R 40 K. pneumoniae KPNIH30 CP009875.1 CG258 258 clade4 M M+R 41 K. pneumoniae KPNIH32 CP009776.1 CG258 258 M M+R 42 K. pneumoniae KPNIH33 CP009773.1 CG258 258 M M+R 43 K. pneumoniae 32192 CP010575.1 CG258 258 M M+R 44 K. pneumoniae 34618 CP010396.1 CG258 258 M M+R 45 K. pneumoniae CAV1596 CP011646.1 ?CP011645.1 CG258 258 M M+R 46 K. pneumoniae 500_1420 NZ_CP011981.1 CG258 258 clade4 M M+R 47 K. pneumoniae UHKPC33 CP011990.1 CG258 258 clade4 M M+R 48 K. pneumoniae DMC1097 CP011978.1 CG258 258 M M+R 49 K. pneumoniae UHKPC07 CP011986.1 CG258 258 clade4 M M+R 55 K. pneumoniae MNCRE69 CP018426.1 CG258 258 M M+R 63 K. pneumoniae MNCRE78 CP018432.1 CG258 258 M M+R 64 K. pneumoniae MNCRE53 CP018436.1 CG258 258 M M+R 66 K. pneumoniae BIC-1 CP022574.1 CG258 258 clade4 M M+R 67 K. pneumoniae AUSMDU00008079 CP022693.1 CG258 258 clade4 M M+R 95 KPNIH36 CP014650.1 CG258 258 clade4 M M+R 104 CR14 CP015395.1 CG258 258 clade4 M M+R 123 CAV1453 CG258 258 M M+R 146 AR_0115 CP020075.1 CG258 258 M M+R 147 AR_0098 CP020110.1 CG258 258 M M+R 148 BK13043 CG258 258 M M+R 153 AR_0047 CG258 258 M M+R 154 AR_0112 "CP021546.1 ,CP021548.1" CG258 258 M M+R 158 AR_0129 CP021716.1 CG258 258 M M+R 160 AR_0113 "CP021756.1,CP021754.1" CG258 258 M M+R 162 AR_0120 CP021835.1 CG258 258 M M+R 163 AR_0125 "CP021861.1,CP021860.1" CG258 258 M M+R 199 AUSMDU00003562 CP025006.1 CG258 258 M M+R 200 AUSMDU00008119 "CP025010.1,CP025009.1" CG258 258 clade4 M M+R 201 NU-CRE047 CP025039.1 CG258 258 M M+R 217 AR_0363 CP027150.1 CG258 258 M M+R 218 AR_0361 CP027158.1 CG258 258 clade4 M M+R 98 Kpn223 273 clade1 clade7 M 209 WCHKP34 273 "clade1,3" M 21 K. pneumoniae KpN01 278 clade3 M 22 K. pneumoniae KpN06 278 clade3 M 203 KP1768 CP025141.1 307 "clade14,17" M+R 204 NR5632 CP025144.1 307 "clade14,24" M+R 205 KP1766 "CP025148.1,CP025147.1" 307 "clade14,24" M+R 188 KSB1_7E 323 M 189 KSB1_4E 323 M 190 KSB2_1B 323 clade21 M 191 KSB1_10J 323 M 58 K. pneumoniae FDAARGOS_445 CG258 340 clade4 clade4 M 59 K. pneumoniae INF274 CG258 340 M 60 K. pneumoniae INF278 CG258 340 M 61 K. pneumoniae INF164 CG258 340 M 62 K. pneumoniae INF163 CG258 340 M 68 K. pneumoniae CAV1042 CG258 340 clade20 M 69 K. pneumoniae CAV1217 CG258 340 M M+R 103 NY9 CP015387.1 CG258 340 M 122 CAV1417 CG258 340 M+R M+R 175 FDAARGOS_436 CG258 340 M 181 FDAARGOS_446 CG258 340 clade4 clade4 M 183 KSB1_5D CG258 340 192 INF158 CG258 340 M 193 INF157 CG258 340 M 194 KSB1_9D CG258 340 M 211 KPNIH49 CP026179.1 359 clade30 M 91 RJF293 374 "clade 2,25" M 23 K. pneumoniae KCTC 2242 375 clade10 M 87 TGH8 383 clade23 M M+R 88 TGH10 383 M 54 K. pneumoniae KPNIH31 392 clade3 M 102 CN1 392 "clade1,3" M 24 K. pneumoniae blaNDM-1 395 M 124 Kp_Goe_62629 395 clade15 M 139 BR7 CP018884.1 CG258 437 clade4 M 140 BR21 CP018887.1 CG258 437 "clade4,7" M 50 K. pneumoniae Kp13 CP003997.1 442 M 79 K. pneumoniae KP8 485 clade10 M 142 GN-2 485 clade10 M 25 K. pneumoniae ATCC 43816 493 M 101 ATCC 35657 505 clade21 M 70 K. pneumoniae KPN_KPC_HUG_07 CP019774.1 CG258 512 clade4 M M+R 107 blood sample 2 CG258 512 M M+R 26 K. pneumoniae 234-12 514 clade5 M 118 H11 659 clade20 M 82 K. pneumoniae KP11 700 M+R 27 K. pneumoniae YH43 906 clade21 M 150 KPN1481 906 M 51 K. pneumoniae CAV1344 CP011622.1 941 M+R 52 K. pneumoniae CAV1193 CP013325.1 941 M+R 167 AR_0107 1161 M 75 K. pneumoniae 69 CP025458.1 CG258 1326 M 53 K. pneumoniae KPNIH29 CP009864.1 1518 M 106 W14 1536 M+R 109 TH1 1536 M+R 78 K. pneumoniae KP7 1941 clade8 M M+R 143 1756 2549 M 100 Kpn555 2623 M 28 K. pneumoniae HKUOPLC ND M+R 173 KpvK54 ND clade22 M 56 missing 72 missing