"Supplementary Table S5: Overlap with the GenAge database. The overlap of our significant genes, or subsets of genes as determined by the clustering analysis, with ""aging"" genes from the GenAge database was determined.  The overlap with ""aging"" genes that were confirmed in Drosophila (""Drosophila only""), as well as orthologs of known ""aging"" genes in other model organisms (""Drosophila + orthologs"") was determined. In addition, the overlap of the GenAge gene lists with the three other longevity E&R datasets (Carnes et al. 2015; Fabian et al. 2018; Remolina et al. 2012) was assessed. The total number of genes per dataset is given in brackets. P was considered significant if < 0.0012 (Bonferroni correction: 0.05 / 43 intersections)."																
																
	GenAge - Drosophila only (188)				GenAge - Drosophila + orthologs (579)											
																
	Observed overlap	Expected overlap	Fold change	P	Observed overlap	Expected overlap	Fold change	P								
All significant genes (676)	10	7.58	1.32	0.228	31	23.33	1.33	0.066								
Developmental diet (222)	4	2.49	1.61	0.238	10	7.66	1.31	0.238								
Age-at-reproduction (154)	0	1.73	0.00	n.a.	3	5.31	0.56	0.905								
Interaction (346)	7	3.88	1.81	0.095	20	11.94	1.67	0.017								
"    ""LE"" genes only  (241)"	5	2.70	1.85	0.135	15	8.32	1.80	0.020								
Carnes et al (1929)	26	21.62	1.20	0.184	70	66.57	1.05	0.344								
Fabian et al (868)	11	9.73	1.13	0.382	33	29.96	1.10	0.306								à
Remolina et al (1006)	17	11.27	1.51	0.060	39	34.72	1.12	0.246