TABLE S1 (Martin Kapun and Thomas Flatt, 2018, 'The adaptive significance of chromosomal inversion polymorphisms in Drosophila melanogaster'', Molecular Ecology). World-wide inversion frequencies of the four common cosmopolitan inversions (In(2L)t, In(2R)NS, In(3L)P and In(3R)Payne) assembled from 34 independent sources that span >50 years of observation on all continents except for South America. Note that inversion frequencies were assessed by different methods, i.e. cytological analyses of polytene chromosomes, estimates from inversion-specific SNP markers and through bioinformatic assembly of the breakpoint regions of individuals.

TABLE S2 (Martin Kapun and Thomas Flatt, 2018, 'The adaptive significance of chromosomal inversion polymorphisms in Drosophila melanogaster', Molecular Ecology). Associations between inversion frequencies and latitude, longitude, altitude, time (measured in decades during wich sampling was performed) and all possible interactions. We tested for correlations between inversion frequencies and different geographic and temporal predictors using multi-way linear models in R. Inversion frequencies were arcsine square root - transformed prior to analysis. We calculated separate inversion-specific models for different geographic areas which are not directly connected by land. The factor 'decade' was excluded from the model whenever samples were collected within a single decade or when sample locations from different decades did not overlap. Due to a lack of data for some geographic regions we could not always use a fully factorial 4-way model. Significant models are highlighted in bold. * p < 0.05; ** p < 0.01; *** p < 0.001. See Table S1 for raw data.