<oai_dc:dc xmlns:dc="http://purl.org/dc/elements/1.1/" xmlns:oai_dc="http://www.openarchives.org/OAI/2.0/oai_dc/" xmlns:xsi="http://www.w3.org/2001/XMLSchema-instance" xsi:schemaLocation="http://www.openarchives.org/OAI/2.0/oai_dc/ http://www.openarchives.org/OAI/2.0/oai_dc.xsd">
  <dc:creator>Schindler, Kevin</dc:creator>
  <dc:creator>Demirci, Gozde</dc:creator>
  <dc:creator>Tran, Bettina</dc:creator>
  <dc:creator>Sovari, Sara Nasiri</dc:creator>
  <dc:creator>Cortat, Youri</dc:creator>
  <dc:creator>De Sousa, Nicolas F. Rosa</dc:creator>
  <dc:creator>Velti, Carola</dc:creator>
  <dc:creator>Chapuis, Baptiste</dc:creator>
  <dc:creator>Crochet, Aurélien</dc:creator>
  <dc:creator>Pavic, Aleksandar</dc:creator>
  <dc:creator>Djuris, Jelena</dc:creator>
  <dc:creator>Salentinig, Stefan</dc:creator>
  <dc:creator>Zobi, Fabio</dc:creator>
  <dc:date>2025</dc:date>
  <dc:description xmlns:ns0="xml" ns0:lang="en">In this study, a library of rhenium di- and tricarbonyl complexes featuring various antimicrobial azoles as monodentate ligands was synthesized and characterized. Their antimicrobial activity was evaluated against both methicillin-sensitive (MSSA) and methicillin-resistant (MRSA) Staphylococcus aureus, and selected compounds were also assessed for cytotoxicity, yielding promising therapeutic indices. Notably, the complexation of antifungal azoles to the rhenium core enhanced antimicrobial efficacy, with a compound exhibiting up to a 32-fold improvement in MIC values relative to the parent azole. Structure-activity relationships indicated that cationic fac-[Re(CO)₃]⁺ complexes consistently outperformed their cis-[Re(CO)₂]⁺ counterparts, and mechanistic studies suggest that active complexes disrupt bacterial membrane integrity and interfere with the electron transport chain. Complementary small-angle X-ray scattering and in silico analysis corroborate these findings, offering insights into the mechanism of action of this family of complexes. </dc:description>
  <dc:format>application/pdf</dc:format>
  <dc:identifier>https://folia.unifr.ch/global/documents/332414</dc:identifier>
  <dc:identifier>https://folia.unifr.ch/documents/332414/files/chembiochem-2025-schindler-boostingantibioticefficacyofazoledrugsagainstmethicillinresistantstaphylococcus.pdf</dc:identifier>
  <dc:identifier>https://folia.unifr.ch/documents/332414/files/esi_cbic.202500368_r1.pdf</dc:identifier>
  <dc:language>eng</dc:language>
  <dc:relation>info:eu-repo/semantics/altIdentifier/doi/10.1002/cbic.202500368</dc:relation>
  <dc:relation>info:eu-repo/semantics/altIdentifier/issn/1439-4227</dc:relation>
  <dc:relation>info:eu-repo/semantics/altIdentifier/issn/1439-7633</dc:relation>
  <dc:rights>info:eu-repo/semantics/openAccess</dc:rights>
  <dc:rights>CC BY-NC</dc:rights>
  <dc:source>ChemBioChem. - Chichester, UK: Wiley. - 2025</dc:source>
  <dc:subject xmlns:ns1="xml" ns1:lang="en">Antimicrobial</dc:subject>
  <dc:subject xmlns:ns2="xml" ns2:lang="en">Rhenium</dc:subject>
  <dc:subject xmlns:ns3="xml" ns3:lang="en">Carbonyl</dc:subject>
  <dc:subject xmlns:ns4="xml" ns4:lang="en">S. Aureus</dc:subject>
  <dc:subject xmlns:ns5="xml" ns5:lang="en">Antifungal Azole</dc:subject>
  <dc:subject>info:eu-repo/classification/udc/54</dc:subject>
  <dc:title xmlns:ns6="xml" ns6:lang="en">Boosting Antibiotic Efficacy of Azole Drugs against Methicillin‐Resistant &lt;i&gt;Staphylococcus Aureus&lt;/i&gt; by Coordination to Rhenium Carbonyl Complexes</dc:title>
  <dc:type>http://purl.org/coar/resource_type/c_6501</dc:type>
</oai_dc:dc>