Nasiri Sovari, Sara Kolly, Isabelle Schindler, Kevin Djuric, Ana Srdic-Rajic, Tatjana Crochet, Aurélien Pavic, Aleksandar Zobi, Fabio 2023 We report the synthesis, characterization, and in vivo evaluation of the anticancer activity of a series of 5- and 6-(halomethyl)-2,2′-bipyridine rhenium tricarbonyl complexes. The study was promoted in order to understand if the presence and position of a reactive halomethyl substituent on the diimine ligand system of fac-[Re(CO)3]+ species may be a key molecular feature for the design of active and non-toxic anticancer agents. Only compounds potentially able to undergo ligand-based alkylating reactions show significant antiproliferative activity against colorectal and pancreatic cell lines. Of the new species presented in this study, one compound (5-(chloromethyl)-2,2′-bipyridine derivative) shows significant inhibition of pancreatic tumour growth in vivo in zebrafish-Panc-1 xenografts. The complex is noticeably effective at 8 μM concentration, lower than its in vitro IC50 values, being also capable of inhibiting in vivo cancer cells dissemination. application/pdf https://folia.unifr.ch/global/documents/330406 https://folia.unifr.ch/documents/330406/files/d2dt04041g.pdf https://folia.unifr.ch/documents/330406/files/d2dt04041g1.pdf eng info:eu-repo/semantics/altIdentifier/doi/10.1039/D2DT04041G info:eu-repo/semantics/altIdentifier/issn/1477-9226 info:eu-repo/semantics/altIdentifier/issn/1477-9234 info:eu-repo/semantics/openAccess CC BY-NC Dalton Transactions. - London, UK: Royal Society of Chemistry (RSC). - 2023, vol. 52, no. 20, p. 6934-6944 rhenium tricarbonyl anticancer info:eu-repo/classification/udc/54 Synthesis, characterization, and <i>in vivo</i> evaluation of the anticancer activity of a series of 5- and 6-(halomethyl)-2,2′-bipyridine rhenium tricarbonyl complexes http://purl.org/coar/resource_type/c_6501