<oai_dc:dc xmlns:dc="http://purl.org/dc/elements/1.1/" xmlns:oai_dc="http://www.openarchives.org/OAI/2.0/oai_dc/" xmlns:xsi="http://www.w3.org/2001/XMLSchema-instance" xsi:schemaLocation="http://www.openarchives.org/OAI/2.0/oai_dc/ http://www.openarchives.org/OAI/2.0/oai_dc.xsd">
  <dc:creator>Stamatis, Caitlin A.</dc:creator>
  <dc:creator>Engelmann, Jan B.</dc:creator>
  <dc:creator>Ziegler, Christiane</dc:creator>
  <dc:creator>Domschke, Katharina</dc:creator>
  <dc:creator>Hasler, Gregor</dc:creator>
  <dc:creator>Timpano, Kiara R.</dc:creator>
  <dc:date>2020</dc:date>
  <dc:description xmlns:ns0="xml" ns0:lang="en">Background and objectives:&#13;
Although approaches combining behavioral genetics and neuroeconomics have advanced models of addiction, no study has synthesized these methods to elucidate mechanisms of competing risk-approachand risk-avoidance in social anxiety (SA). Grounded in dual-mode models of serotonergic systems and self-regulation, this study investigated associations between SA, serotonin transporter 5-HTT (LPR; rs25531) and receptor 5-HT1A genes, and risk-taking on behavioral and self-report measures.&#13;
&#13;
Design and methods:&#13;
Young adults (N = 309) completed a neuroeconomic task measuring gambling attractiveness (δ), reward probability discrimination (γ), and risk attitudes (α). Risk genotypes included 5-HTT (LPR; rs25531) low-expression variants (SS/SLG/LGLG), and 5-HT1A (rs6295) GG.&#13;
&#13;
Results:&#13;
Path analysis revealed that SA related to increased gambling attractiveness, but only for 5-HT1A risk groups. Although the 5-HTT (LPR; rs25531) risk genotypes and self-reported SA predicted lower social risk-taking, high-SA individuals who exhibited more accurate reward probability discrimination (γ) reported taking increased social risks.&#13;
&#13;
Conclusion:&#13;
In line with dual-mode models, results suggest that SA predicts behavioral risk-approach at the basic decision-making level, along with self-reported social risk-avoidance, modulated by serotonergic genotypes. High-SA individuals with more accurate assessments of reward probabilities may engage in greater social risk-taking, perhaps reflecting an adaptive tendency to approach feared situations.</dc:description>
  <dc:format>application/pdf</dc:format>
  <dc:identifier>https://folia.unifr.ch/global/documents/327492</dc:identifier>
  <dc:identifier>https://folia.unifr.ch/documents/327492/files/stamatisetal.2020.pdf</dc:identifier>
  <dc:language>eng</dc:language>
  <dc:relation>info:eu-repo/semantics/altIdentifier/doi/10.1080/10615806.2020.1722597</dc:relation>
  <dc:relation>info:eu-repo/semantics/altIdentifier/issn/1061-5806</dc:relation>
  <dc:rights>info:eu-repo/semantics/openAccess</dc:rights>
  <dc:rights>License undefined</dc:rights>
  <dc:source>ANXIETY, STRESS, &amp; COPING. - London : Informa UK Limited. - 2020, vol. 33, no. 2, p. 176-192</dc:source>
  <dc:subject xmlns:ns1="xml" ns1:lang="en"> Social anxiety</dc:subject>
  <dc:subject xmlns:ns2="xml" ns2:lang="en">neuroeconomics</dc:subject>
  <dc:subject xmlns:ns3="xml" ns3:lang="en">5-HT1A</dc:subject>
  <dc:subject xmlns:ns4="xml" ns4:lang="en">5-HTT (LPR; rs25531)</dc:subject>
  <dc:subject xmlns:ns5="xml" ns5:lang="en">risk-taking</dc:subject>
  <dc:subject xmlns:ns6="xml" ns6:lang="en">decision-making</dc:subject>
  <dc:subject>info:eu-repo/classification/udc/61</dc:subject>
  <dc:title xmlns:ns7="xml" ns7:lang="en">A neuroeconomic investigation of &lt;i&gt;5-HTT&lt;/i&gt;/&lt;i&gt;5-HT1A&lt;/i&gt; gene variation, social anxiety, and risk-taking behavior</dc:title>
  <dc:type>http://purl.org/coar/resource_type/c_6501</dc:type>
</oai_dc:dc>