Hasler, Gregor Gergen, Peter J. Kleinbaum, David G. Ajdacic, Vladeta Gamma, Alex Eich, Dominique Rössler, Wulf Angst, Jules 2005 Rationale: Psychologic factors are increasingly recognized to influence the onset and course of asthma. Previous cross-sectional community-based studies have provided evidence for a relatively specific association between asthma and panic. Objectives: To examine concurrent and longitudinal associations between asthma and panic in young adults. Measurements and main results: Prospective community-based cohort study of young adults (n = 591) followed between ages 19 and 40. Information was derived from six subsequent semistructured diagnostic interviews conducted by professionals. Cross-sectionally (over the whole study period), asthma was more strongly associated with panic disorder (odds ratio [OR] = 4.0; 95% confidence interval [CI], 1.7, 9.3) than with any panic, which included panic disorder and panic attacks (OR = 2.1; 95% CI, 1.1, 4.5). Longitudinally, after adjusting for potentially confounding variables, active asthma predicted subsequent panic disorder (OR = 4.5; 95% CI, 1.1, 20.1), and the presence of panic disorder predicted subsequent asthma activity (OR = 6.3; 95% CI, 2.8, 14.0). Asthma predicted any panic (OR = 2.7; 95% CI, 1.1, 7.1), whereas any panic did not predict subsequent asthma activity. Associations were stronger in smokers than in nonsmokers, and stronger in women than in men. Smoking, early-childhood anxiety, and a family history of allergy were important confounders of the asthma-panic association. Conclusions: This is the first long-term follow-up study on asthma and panic. It showed dose-response-type relationships between panic and asthma, and bidirectional longitudinal associations between the two conditions. It provided evidence for familial factors and smoking as possible shared etiologic explanations. application/pdf https://folia.unifr.ch/global/documents/327487 https://folia.unifr.ch/documents/327487/files/hasleretal.2005.pdf eng info:eu-repo/semantics/altIdentifier/doi/10.1164/rccm.200412-1669OC info:eu-repo/semantics/altIdentifier/issn/1073-449X info:eu-repo/semantics/openAccess License undefined American Journal of Respiratory and Critical Care Medicine. - New York City : American Thoracic Society. - 2005, vol. 171, no. 11, p. 1224-1230 Critical Care and Intensive Care Medicine Pulmonary and Respiratory Medicine Anxiety Child development Respiratory tract disease Sex Smoking info:eu-repo/classification/udc/616 Asthma and Panic in Young Adults: a 20-year prospective community study http://purl.org/coar/resource_type/c_6501