<oai_dc:dc xmlns:dc="http://purl.org/dc/elements/1.1/" xmlns:oai_dc="http://www.openarchives.org/OAI/2.0/oai_dc/" xmlns:xsi="http://www.w3.org/2001/XMLSchema-instance" xsi:schemaLocation="http://www.openarchives.org/OAI/2.0/oai_dc/ http://www.openarchives.org/OAI/2.0/oai_dc.xsd">
  <dc:creator>Anaraki, Neda Iranpour</dc:creator>
  <dc:creator>Sadeghpour, Amin</dc:creator>
  <dc:creator>Iranshahi, Kamran</dc:creator>
  <dc:creator>Toncelli, Claudio</dc:creator>
  <dc:creator>Cendrowska, Urszula</dc:creator>
  <dc:creator>Stellacci, Francesco</dc:creator>
  <dc:creator>Dommann, Alex</dc:creator>
  <dc:creator>Wick, Peter</dc:creator>
  <dc:creator>Neels, Antonia</dc:creator>
  <dc:date>2020-07-28</dc:date>
  <dc:description xmlns:ns0="xml" ns0:lang="en">Nanoparticle (NP) colloidal stability plays a crucial role in biomedical application not  only for human and environmental safety but also for NP efficiency and functionality.  NP agglomeration is considered as a possible process in monodispersed NP colloidal  solutions, which drastically affects colloidal stability. This process is triggered by  changes in the physicochemical properties of the surrounding media, such as ionic  strength (IS), pH value, or presence of biomolecules. Despite different available  characterization methods for nanoparticles (NPs), there is a lack of information about  the underlying mechanisms at the early stage of dynamic behaviors, namely changing  in NP size distribution and structure while placing them from a stable colloidal solution  to a new media like biological fluids. In this study, an advanced in situ approach is  presented that combines small angle X-ray scattering (SAXS) and microfluidics,  allowing label-free, direct, time-resolved, and dynamic observations of the early stage  of NP interaction/agglomeration initiated by environmental changes. It is shown for  silica NPs that the presence of protein in the media enormously accelerates the NP  agglomeration process compared to respective changes in IS and pH. High IS results  in a staring agglomeration process after 40 min, though, in case of protein presence in  media, this time decreased enormously to 48 s. These time scales show that this  method is sensitive and precise in depicting the dynamics of fast and slow NP  interactions in colloidal conditions and therefore supports understanding the colloidal  stability of NPs in various media concluding in safe and efficient NP designing for  various applications.</dc:description>
  <dc:format>application/pdf</dc:format>
  <dc:identifier>https://folia.unifr.ch/global/documents/309113</dc:identifier>
  <dc:identifier>https://folia.unifr.ch/documents/309113/files/nee_nat.pdf</dc:identifier>
  <dc:language>eng</dc:language>
  <dc:relation>info:eu-repo/semantics/altIdentifier/doi/10.1007/s12274-020-2940-4</dc:relation>
  <dc:rights>info:eu-repo/semantics/openAccess</dc:rights>
  <dc:rights>License undefined</dc:rights>
  <dc:source>Nano Research. - 2020, vol. 13, no. 10, p. 2847–2856</dc:source>
  <dc:subject>info:eu-repo/classification/udc/54</dc:subject>
  <dc:title xmlns:ns1="xml" ns1:lang="en">New approach for time-resolved and dynamic investigations on nanoparticles agglomeration</dc:title>
  <dc:type>http://purl.org/coar/resource_type/c_6501</dc:type>
</oai_dc:dc>