<oai_dc:dc xmlns:dc="http://purl.org/dc/elements/1.1/" xmlns:oai_dc="http://www.openarchives.org/OAI/2.0/oai_dc/" xmlns:xsi="http://www.w3.org/2001/XMLSchema-instance" xsi:schemaLocation="http://www.openarchives.org/OAI/2.0/oai_dc/ http://www.openarchives.org/OAI/2.0/oai_dc.xsd">
  <dc:creator>Poirel, Laurent</dc:creator>
  <dc:creator>Vuillemin, Xavier</dc:creator>
  <dc:creator>Juhas, Mario</dc:creator>
  <dc:creator>Masseron, Amandine</dc:creator>
  <dc:creator>Bechtel-Grosch, Ursina</dc:creator>
  <dc:creator>Tiziani, Simon</dc:creator>
  <dc:creator>Mancini, Stefano</dc:creator>
  <dc:creator>Nordmann, Patrice</dc:creator>
  <dc:date>2020-07-22</dc:date>
  <dc:description xmlns:ns0="xml" ns0:lang="en">KPC-50 is a KPC-3 variant identified from a Klebsiella pneumoniae clinical isolate  recovered in Switzerland in 2019. Compared to KPC-3, KPC-50 shows (i) a three- amino-acid insertion (Glu-Ala-Val) between amino acids 276 and 277, (ii) an increased  affinity to ceftazidime, (iii) a decreased sensitivity to avibactam, explaining the  ceftazidime-avibactam resistance, and (iv) an association with a sharp reduction of its  carbapenemase activity.</dc:description>
  <dc:format>application/pdf</dc:format>
  <dc:identifier>https://folia.unifr.ch/global/documents/309065</dc:identifier>
  <dc:identifier>https://folia.unifr.ch/documents/309065/files/poi_kcr_sm.pdf</dc:identifier>
  <dc:identifier>https://folia.unifr.ch/documents/309065/files/poi_kcr.pdf</dc:identifier>
  <dc:language>eng</dc:language>
  <dc:relation>info:eu-repo/semantics/altIdentifier/doi/10.1128/AAC.00321-20</dc:relation>
  <dc:rights>info:eu-repo/semantics/openAccess</dc:rights>
  <dc:rights>License undefined</dc:rights>
  <dc:source>Antimicrobial Agents and Chemotherapy. - 2020, vol. 64, no. 8, p. 10.1128/aac.00321-20</dc:source>
  <dc:subject>info:eu-repo/classification/udc/57</dc:subject>
  <dc:title xmlns:ns1="xml" ns1:lang="en">KPC-50 confers resistance to ceftazidime-avibactam associated with reduced carbapenemase activity</dc:title>
  <dc:type>http://purl.org/coar/resource_type/c_6501</dc:type>
</oai_dc:dc>