<oai_dc:dc xmlns:dc="http://purl.org/dc/elements/1.1/" xmlns:oai_dc="http://www.openarchives.org/OAI/2.0/oai_dc/" xmlns:xsi="http://www.w3.org/2001/XMLSchema-instance" xsi:schemaLocation="http://www.openarchives.org/OAI/2.0/oai_dc/ http://www.openarchives.org/OAI/2.0/oai_dc.xsd">
  <dc:creator>Berberich, Bettina</dc:creator>
  <dc:creator>Thriene, Kerstin</dc:creator>
  <dc:creator>Gretzmeier, Christine</dc:creator>
  <dc:creator>Kühl, Tobias</dc:creator>
  <dc:creator>Bayer, Hans</dc:creator>
  <dc:creator>Athanasiou, Ioannis</dc:creator>
  <dc:creator>Rafei-Shamsabadi, David Ali</dc:creator>
  <dc:creator>Bruckner-Tuderman, Leena</dc:creator>
  <dc:creator>Nyström, Alexander</dc:creator>
  <dc:creator>Kiritsi, Dimitra</dc:creator>
  <dc:creator>Dengjel, Jörn</dc:creator>
  <dc:date>2020-11-01</dc:date>
  <dc:description xmlns:ns0="xml" ns0:lang="en">Chronic skin wounds accompany many prevalent age-related diseases and are a  major cause of morbidity and mortality. Both keratinocytes and fibroblasts contribute to  the pathomechanisms in chronic skin wounds. Dysregulated pathways in the  epidermis have been extensively studied, but little is known of the influence of dermal  fibroblasts on chronic wounding. We isolated fibroblasts from chronic wounds,  propagated them in vitro, and analyzed them using proteomic profiling in combination  with functional characterization of the proteomic changes. Chronic wound–associated  fibroblasts exhibit a unique proteome profile characteristic of lysosomal dysfunction  and dysregulated TGFβ signaling. They display a decreased propensity for cell  proliferation and migration, combined with an enhanced ability to contract the  extracellular matrix. With these properties, chronic wound–associated fibroblasts  actively contribute to pathological inabilities to close wounds and represent potential  targets for pharmacological interference for changing cellular phenotypes.</dc:description>
  <dc:format>application/pdf</dc:format>
  <dc:identifier>https://folia.unifr.ch/global/documents/309046</dc:identifier>
  <dc:identifier>https://folia.unifr.ch/documents/309046/files/den_ppf.pdf</dc:identifier>
  <dc:identifier>https://folia.unifr.ch/documents/309046/files/Table_S1._Identified_Protein_Groups.txt</dc:identifier>
  <dc:identifier>https://folia.unifr.ch/documents/309046/files/Table_S2._Proteins_in_Cluster_2.txt</dc:identifier>
  <dc:identifier>https://folia.unifr.ch/documents/309046/files/Table_S3._Proteins_in_Cluster_3.txt</dc:identifier>
  <dc:identifier>https://folia.unifr.ch/documents/309046/files/Table_S4._Proteins_in_Cluster_4.txt</dc:identifier>
  <dc:identifier>https://folia.unifr.ch/documents/309046/files/Table_S5._Proteins_in_Cluster_5.txt</dc:identifier>
  <dc:language>eng</dc:language>
  <dc:relation>info:eu-repo/semantics/altIdentifier/doi/10.1016/j.jid.2020.02.040</dc:relation>
  <dc:rights>info:eu-repo/semantics/openAccess</dc:rights>
  <dc:rights>License undefined</dc:rights>
  <dc:source>Journal of Investigative Dermatology. - 2020, vol. 140, no. 11, p. 2280-2290.e4</dc:source>
  <dc:subject>info:eu-repo/classification/udc/57</dc:subject>
  <dc:title xmlns:ns1="xml" ns1:lang="en">Proteomic profiling of fibroblasts isolated from chronic wounds identifies disease-relevant signaling pathways</dc:title>
  <dc:type>http://purl.org/coar/resource_type/c_6501</dc:type>
</oai_dc:dc>