<oai_dc:dc xmlns:dc="http://purl.org/dc/elements/1.1/" xmlns:oai_dc="http://www.openarchives.org/OAI/2.0/oai_dc/" xmlns:xsi="http://www.w3.org/2001/XMLSchema-instance" xsi:schemaLocation="http://www.openarchives.org/OAI/2.0/oai_dc/ http://www.openarchives.org/OAI/2.0/oai_dc.xsd">
  <dc:creator>Zhou, Ying</dc:creator>
  <dc:creator>Tian, Dongxing</dc:creator>
  <dc:creator>Tang, Yu</dc:creator>
  <dc:creator>Yu, Lianhua</dc:creator>
  <dc:creator>Huang, Yunkun</dc:creator>
  <dc:creator>Li, Gang</dc:creator>
  <dc:creator>Li, Meng</dc:creator>
  <dc:creator>Wang, Yong</dc:creator>
  <dc:creator>Yang, Zehua</dc:creator>
  <dc:creator>Poirel, Laurent</dc:creator>
  <dc:creator>Jiang, Xiaofei</dc:creator>
  <dc:date>2020-08-01</dc:date>
  <dc:description xmlns:ns0="xml" ns0:lang="en">Klebsiella pneumoniae carbapenemase (KPC)-producing K. pneumoniae (KPC-KP)  have disseminated worldwide and are a major threat to public health. The multidrug- resistant (MDR)-phenotype of KPC-KP are commonly associated with the presence of  high molecular weight blaKPC plasmids. Restriction-modification (R-M) systems  provide bacteria with innate defense against plasmids or other infectious gene  elements. As blaKPC plasmids are favored by such MDR K. pneumoniae, it was of  interest to examine the co-distribution of R-M and acquired blaKPC plasmids in KPC- KP. A total of 459 clinical K. pneumoniae isolates in China and 217 global whole- genome sequences in GenBank were collected to determine the prevalence of type I  R-M systems. The type I R-M systems were scarce in the KPC-positive group and  high-risk Klebsiella pneumoniae clonal group 258 (CG258). The polymorphisms of  type I R-M observed in K. pneumoniae revealed the ubiquity of their recognition  sequences in DNA; therefore, the type I R-M systems could attack most invading DNA  elements, such as blaKPC genes. Overall, this work indicated the type I R-M systems  may impact the acquisition of blaKPC genes in K. pneumoniae.</dc:description>
  <dc:format>application/pdf</dc:format>
  <dc:identifier>https://folia.unifr.ch/global/documents/308900</dc:identifier>
  <dc:identifier>https://folia.unifr.ch/documents/308900/files/poi_hrk.pdf</dc:identifier>
  <dc:identifier>https://folia.unifr.ch/documents/308900/files/poi_hrk_sm.pdf</dc:identifier>
  <dc:identifier>https://folia.unifr.ch/documents/308900/files/a-217_global_strains.txt</dc:identifier>
  <dc:identifier>https://folia.unifr.ch/documents/308900/files/b-I-R-M_plasmid_borne.txt</dc:identifier>
  <dc:identifier>https://folia.unifr.ch/documents/308900/files/C-R-M_information.txt</dc:identifier>
  <dc:language>eng</dc:language>
  <dc:relation>info:eu-repo/semantics/altIdentifier/doi/10.1016/j.ijantimicag.2020.106050</dc:relation>
  <dc:rights>info:eu-repo/semantics/openAccess</dc:rights>
  <dc:rights>License undefined</dc:rights>
  <dc:source>International Journal of Antimicrobial Agents. - 2020, vol. 56, no. 2, p. 106050</dc:source>
  <dc:subject>info:eu-repo/classification/udc/57</dc:subject>
  <dc:title xmlns:ns1="xml" ns1:lang="en">High-risk KPC-producing Klebsiella pneumoniae lack type I R-M systems</dc:title>
  <dc:type>http://purl.org/coar/resource_type/c_6501</dc:type>
</oai_dc:dc>