Zurbuchen, Anouck Lanzi, Stefano Voirol, Ludovic Trindade, Cybele Barboza Gojanovic, Boris Kayser, Bengt Bourdillon, Nicolas Chenevière, Xavier Malatesta, Davide 2020-06-04 The present study aimed to determine whether whole-body fat oxidation and muscle deoxygenation kinetics parameters during exercise were related in individuals with different aerobic fitness levels.Methods: Eleven cyclists [peak oxygen uptake (V.O2peak): 64.9 ± 3.9 mL⋅kg–1⋅min–1] and 11 active individuals (V.O2peak: 49.1 ± 7.4 mL⋅kg–1⋅min–1) performed a maximal incremental cycling test to determine V.O2peak and a submaximal incremental cycling test to assess whole-body fat oxidation using indirect calorimetry and muscle deoxygenation kinetics of the vastus lateralis (VL) using near-infrared spectroscopy (NIRS). A sinusoidal (SIN) model was used to characterize fat oxidation kinetics and to determine the intensity (Fatmax) eliciting maximal fat oxidation (MFO). The muscle deoxygenation response was fitted with a double linear model. The slope of the first parts of the kinetics (a1) and the breakpoint ([HHb]BP) were determined.Results: MFO (p = 0.01) and absolute fat oxidation rates between 20 and 65% V.O2peak were higher in cyclists than in active participants (p < 0.05), while Fatmax occurred at a higher absolute exercise intensity (p = 0.01). a1 was lower in cyclists (p = 0.02) and [HHb]BP occurred at a higher absolute intensity (p < 0.001) than in active individuals. V.O2peak was strongly correlated with MFO, Fatmax, and [HHb]BP (r = 0.65–0.88, p ≤ 0.001). MFO and Fatmax were both correlated with [HHb]BP (r = 0.66, p = 0.01 and r = 0.68, p < 0.001, respectively) and tended to be negatively correlated with a1 (r = -0.41, p = 0.06 for both).Conclusion: This study showed that whole-body fat oxidation and muscle deoxygenation kinetics were both related to aerobic fitness and that a relationship between the two kinetics exists. Individuals with greater aerobic fitness may have a delayed reliance on glycolytic metabolism at higher exercise intensities because of a longer maintained balance between O2 delivery and consumption supporting higher fat oxidation rates. application/pdf https://folia.unifr.ch/global/documents/308707 https://folia.unifr.ch/documents/308707/files/zur_fok.pdf eng info:eu-repo/semantics/altIdentifier/doi/10.3389/fphys.2020.00571 info:eu-repo/semantics/openAccess License undefined Frontiers in Physiology. - 2020, vol. 11, p. 571 info:eu-repo/classification/udc/796 Fat oxidation kinetics is related to muscle deoxygenation kinetics during exercise http://purl.org/coar/resource_type/c_6501