<oai_dc:dc xmlns:dc="http://purl.org/dc/elements/1.1/" xmlns:oai_dc="http://www.openarchives.org/OAI/2.0/oai_dc/" xmlns:xsi="http://www.w3.org/2001/XMLSchema-instance" xsi:schemaLocation="http://www.openarchives.org/OAI/2.0/oai_dc/ http://www.openarchives.org/OAI/2.0/oai_dc.xsd">
  <dc:creator>Etter, Marco F.</dc:creator>
  <dc:creator>Dellenbach, Daria</dc:creator>
  <dc:creator>Petri-Fink, Alke</dc:creator>
  <dc:creator>Rothen-Rutishauser, Barbara</dc:creator>
  <dc:creator>Landau, Ehud M.</dc:creator>
  <dc:creator>Fong, Wye-Khay</dc:creator>
  <dc:date>2020-03-07</dc:date>
  <dc:description xmlns:ns0="xml" ns0:lang="en">The aqueous channel size of lipidic cubic phases can be a limiting factor for certain  applications. For this reason, additives have been used to exquisitely control their  nanostructure. In this study, two families of primary phosphoesters have been  designed, synthesised and utilised to determine the effect of the positioning of the  guest additive at the interface of the host mesophase, and to contrast the effect of  headgroup ionisation and protonation. A general methodology has been developed to  produce primary phosphoesters, and a unique use of 31P NMR has been used in  order to systematically investigate the influence of these additives on monoolein- and  phytantriol-based bulk lipidic cubic phases and dispersed cubosomes. In general, di- phosphorylated additives exhibit a greater effect upon lipid packing than the mono-  and tri-phosphorylated molecules due to their optimal positioning. In dispersion, the  protonation state of the phosphate headgroups was manipulated by altering the pH,  where shifts in pKa determined by 31P NMR were used as a fluorescent label-free  method to identify the location and ionisation state of the phosphate additives. This  study systematically evaluates the influence of the positioning of the additive,  headgroup size and charge of phosphorylated lipids on the behaviour of lipidic  mesophases.</dc:description>
  <dc:format>application/pdf</dc:format>
  <dc:identifier>https://folia.unifr.ch/global/documents/308550</dc:identifier>
  <dc:identifier>https://folia.unifr.ch/documents/308550/files/fin_uaa.pdf</dc:identifier>
  <dc:identifier>https://folia.unifr.ch/documents/308550/files/fin_uaa_sm.pdf</dc:identifier>
  <dc:language>eng</dc:language>
  <dc:relation>info:eu-repo/semantics/altIdentifier/doi/10.1016/j.jcis.2019.11.087</dc:relation>
  <dc:rights>info:eu-repo/semantics/openAccess</dc:rights>
  <dc:rights>License undefined</dc:rights>
  <dc:source>Journal of Colloid and Interface Science. - 2020, vol. 562, p. 502–510</dc:source>
  <dc:subject>info:eu-repo/classification/udc/54</dc:subject>
  <dc:title xmlns:ns1="xml" ns1:lang="en">Understanding the assembly of amphiphilic additives in bulk and dispersed non-lamellar lipid-based matrices: Phosphorylation, H-bonding and ionisation</dc:title>
  <dc:type>http://purl.org/coar/resource_type/c_6501</dc:type>
</oai_dc:dc>