<oai_dc:dc xmlns:dc="http://purl.org/dc/elements/1.1/" xmlns:oai_dc="http://www.openarchives.org/OAI/2.0/oai_dc/" xmlns:xsi="http://www.w3.org/2001/XMLSchema-instance" xsi:schemaLocation="http://www.openarchives.org/OAI/2.0/oai_dc/ http://www.openarchives.org/OAI/2.0/oai_dc.xsd">
  <dc:creator>Mbagwu, Smart Ikechukwu</dc:creator>
  <dc:creator>Filgueira, Luis</dc:creator>
  <dc:date>2020-01-06</dc:date>
  <dc:description xmlns:ns0="xml" ns0:lang="en">Cerebral microvascular endothelial cells (CMVECs) line the vascular system of the  brain and are the chief cells in the formation and function of the blood brain barrier  (BBB). These cells are heterogeneous along the cerebral vasculature and any  dysfunctional state in these cells can result in a local loss of function of the BBB in any  region of the brain. There is currently no report on the distribution and variation of the  CMVECs in different brain regions in humans. This study investigated microcirculation  in the adult human brain by the characterization of the expression pattern of brain  endothelial cell markers in different brain regions. Five different brain regions  consisting of the visual cortex, the hippocampus, the precentral gyrus, the postcentral  gyrus, and the rhinal cortex obtained from three normal adult human brain specimens  were studied and analyzed for the expression of the endothelial cell markers: cluster  of differentiation 31 (CD31) and von-Willebrand-Factor (vWF) through  immunohistochemistry. We observed differences in the expression pattern of CD31  and vWF between the gray matter and the white matter in the brain regions.  Furthermore, there were also regional variations in the pattern of expression of the  endothelial cell biomarkers. Thus, this suggests differences in the nature of  vascularization in various regions of the human brain. These observations also  suggest the existence of variation in structure and function of different brain regions,  which could reflect in the pathophysiological outcomes in a diseased state.</dc:description>
  <dc:format>application/pdf</dc:format>
  <dc:identifier>https://folia.unifr.ch/global/documents/308549</dc:identifier>
  <dc:identifier>https://folia.unifr.ch/documents/308549/files/fil_dec.pdf</dc:identifier>
  <dc:language>eng</dc:language>
  <dc:relation>info:eu-repo/semantics/altIdentifier/doi/10.3390/brainsci10010031</dc:relation>
  <dc:rights>info:eu-repo/semantics/openAccess</dc:rights>
  <dc:rights>License undefined</dc:rights>
  <dc:source>Brain Sciences. - 2020, vol. 10, no. 1, p. 31</dc:source>
  <dc:subject>info:eu-repo/classification/udc/57</dc:subject>
  <dc:title xmlns:ns1="xml" ns1:lang="en">Differential expression of CD31 and von Willebrand factor on endothelial cells in different regions of the human brain: potential implications for cerebral malaria pathogenesis</dc:title>
  <dc:type>http://purl.org/coar/resource_type/c_6501</dc:type>
</oai_dc:dc>