<oai_dc:dc xmlns:dc="http://purl.org/dc/elements/1.1/" xmlns:oai_dc="http://www.openarchives.org/OAI/2.0/oai_dc/" xmlns:xsi="http://www.w3.org/2001/XMLSchema-instance" xsi:schemaLocation="http://www.openarchives.org/OAI/2.0/oai_dc/ http://www.openarchives.org/OAI/2.0/oai_dc.xsd">
  <dc:creator>Kieffer, Nicolas</dc:creator>
  <dc:creator>Poirel, Laurent</dc:creator>
  <dc:creator>Mueller, Linda</dc:creator>
  <dc:creator>Mancini, Stefano</dc:creator>
  <dc:creator>Nordmann, Patrice</dc:creator>
  <dc:date>2020-04-21</dc:date>
  <dc:description xmlns:ns0="xml" ns0:lang="en">A fosfomycin-resistant and carbapenemase (OXA-48)-producing Klebsiella  pneumoniae isolate was recovered, and whole-genome sequencing revealed  ISEcp1-blaCTX-M-14b tandemly inserted upstream of the chromosomally  encoded lysR-fosA locus. Quantitative evaluation of the expression of lysR and  fosA genes showed that this insertion brought a strong hybrid promoter leading  to overexpression of the fosA gene, resulting in fosfomycin resistance. This  work showed the concomitant acquisition of resistance to broad-spectrum  cephalosporins and fosfomycin due to a single genetic event.</dc:description>
  <dc:format>application/pdf</dc:format>
  <dc:identifier>https://folia.unifr.ch/global/documents/308516</dc:identifier>
  <dc:identifier>https://folia.unifr.ch/documents/308516/files/nor_imt.pdf</dc:identifier>
  <dc:language>eng</dc:language>
  <dc:relation>info:eu-repo/semantics/altIdentifier/doi/10.1128/AAC.00150-20</dc:relation>
  <dc:rights>info:eu-repo/semantics/openAccess</dc:rights>
  <dc:rights>License undefined</dc:rights>
  <dc:source>Antimicrobial Agents and Chemotherapy. - 2020, vol. 64, no. 5, p. 10.1128/aac.00150-20</dc:source>
  <dc:subject>info:eu-repo/classification/udc/57</dc:subject>
  <dc:title xmlns:ns1="xml" ns1:lang="en">ISEcp1 mediated transposition leads to fosfomycin and broad-spectrum cephalosporin resistance in Klebsiella pneumoniae</dc:title>
  <dc:type>http://purl.org/coar/resource_type/c_6501</dc:type>
</oai_dc:dc>