<oai_dc:dc xmlns:dc="http://purl.org/dc/elements/1.1/" xmlns:oai_dc="http://www.openarchives.org/OAI/2.0/oai_dc/" xmlns:xsi="http://www.w3.org/2001/XMLSchema-instance" xsi:schemaLocation="http://www.openarchives.org/OAI/2.0/oai_dc/ http://www.openarchives.org/OAI/2.0/oai_dc.xsd">
  <dc:creator>Zimmermann, Petra</dc:creator>
  <dc:creator>Perrett, Kirsten P.</dc:creator>
  <dc:creator>Ritz, Nicole</dc:creator>
  <dc:creator>Flanagan, Katie L.</dc:creator>
  <dc:creator>Robins-Browne, Roy</dc:creator>
  <dc:creator>Klis, Fiona R. M. van der</dc:creator>
  <dc:creator>Curtis, Nigel</dc:creator>
  <dc:creator>the MIS BAIR group</dc:creator>
  <dc:date>2019</dc:date>
  <dc:description xmlns:ns0="xml" ns0:lang="en">Aim We investigated the effect of early-life factors, namely sex, delivery mode, feeding  method and antibiotic exposure, on antibody responses to routine vaccinations  administered during the first year of life. Methods One and seven months after the  primary course of routine vaccines and 1 month after routine vaccines at 12 months of  age, antibodies against 26 vaccine antigens were measured in 398 healthy infants.  The geometric mean concentration (GMC) of antibodies (adjusted for effect modifiers  with multiple linear regression) and the seroprotection rate for each vaccine were  compared for each early-life factor. Results Sex had an influence on GMCs. Antibody  concentrations were significantly lower at 7 months of age in females for tetanus and  filamentous haemagglutinin and at 13 months of age for pertactin. In contrast, at 13  months of age, antibody concentrations were significantly higher in females for polio  type 3, pneumococcal serotype 6A and measles. Sex did not have an influence on  seroprotection rates. Delivery mode, feeding method and antibiotic exposure did not  exert a substantial influence on vaccine antibody concentrations. Conclusion There is  a difference between males and females in the humoral response to routine  vaccinations in the first year of life. MIS BAIR group: Veronica Abruzzo, Katie Allen, Rhian Bonnici, Dan Casalaz, Hannah Elborough, Bridget Freyne,  Kaya Gardiner, Susie Germano, Tobias Kollmann, Nicole Messina, Clare Morrison, Helder Nakaya, Anne Louise  Ponsonby, Frank Shann, Mike South, Peter Vuillermin</dc:description>
  <dc:format>application/pdf</dc:format>
  <dc:identifier>https://folia.unifr.ch/global/documents/308255</dc:identifier>
  <dc:identifier>https://folia.unifr.ch/documents/308255/files/zim_bsi.pdf</dc:identifier>
  <dc:identifier>https://folia.unifr.ch/documents/308255/files/zim_bsi_sm.pdf</dc:identifier>
  <dc:language>eng</dc:language>
  <dc:relation>info:eu-repo/semantics/altIdentifier/doi/10.1111/apa.14932</dc:relation>
  <dc:rights>info:eu-repo/semantics/openAccess</dc:rights>
  <dc:rights>License undefined</dc:rights>
  <dc:source>Acta Paediatrica. - 2020, vol. 109, no. 1, p. 147-157</dc:source>
  <dc:subject>info:eu-repo/classification/udc/61</dc:subject>
  <dc:title xmlns:ns1="xml" ns1:lang="en">Biological sex influences antibody responses to routine vaccinations in the first year of life</dc:title>
  <dc:type>http://purl.org/coar/resource_type/c_6501</dc:type>
</oai_dc:dc>