Aires-de-Sousa, Marta Ortiz de la Rosa, José Manuel Gonçalves, Maria Luísa Pereira, Ana Luísa Nordmann, Patrice Poirel, Laurent 2019 We aimed to provide updated epidemiologic data on carbapenem-resistant Klebsiella pneumoniae in Portugal by characterizing all isolates (N = 46) recovered during 2013– 2018 in a 123-bed hospital in Lisbon. We identified blaKPC-3 (n = 36), blaOXA-181 (n = 9), and blaGES-5 (n = 8) carbapenemase genes and observed co-occurrence of blaKPC-3 and blaGES-5 in 7 isolates. A single GES-5–producing isolate co-produced the extended-spectrum β-lactamase BEL-1; both corresponding genes were co- located on the same ColE1-like plasmid. The blaOXA-181 gene was always located on an IncX3 plasmid, whereas blaKPC-3 was carried on IncN, IncFII, IncFIB, and IncFIIA plasmid types. The 46 isolates were distributed into 13 pulsotypes and 9 sequence types. All isolates remained susceptible to ceftazidime/avibactam, but some exhibited reduced antimicrobial susceptibility (MIC = 3 mg/L). application/pdf https://folia.unifr.ch/global/documents/308217 https://folia.unifr.ch/documents/308217/files/nor_ecp.pdf eng info:eu-repo/semantics/altIdentifier/doi/10.3201/eid2509.190656 info:eu-repo/semantics/openAccess License undefined Emerging Infectious Diseases. - 2019, vol. 25, no. 9, p. 1632–1638 info:eu-repo/classification/udc/57 Epidemiology of Carbapenemase-Producing Klebsiella pneumoniae in a Hospital, Portugal http://purl.org/coar/resource_type/c_6501