<oai_dc:dc xmlns:dc="http://purl.org/dc/elements/1.1/" xmlns:oai_dc="http://www.openarchives.org/OAI/2.0/oai_dc/" xmlns:xsi="http://www.w3.org/2001/XMLSchema-instance" xsi:schemaLocation="http://www.openarchives.org/OAI/2.0/oai_dc/ http://www.openarchives.org/OAI/2.0/oai_dc.xsd">
  <dc:creator>Zabara, Mahsa</dc:creator>
  <dc:creator>Senturk, Berna</dc:creator>
  <dc:creator>Gontsarik, Mark</dc:creator>
  <dc:creator>Ren, Qun</dc:creator>
  <dc:creator>Rottmar, Markus</dc:creator>
  <dc:creator>Maniura-Weber, Katharina</dc:creator>
  <dc:creator>Mezzenga, Raffaele</dc:creator>
  <dc:creator>Bolisetty, Sreenath</dc:creator>
  <dc:creator>Salentinig, Stefan</dc:creator>
  <dc:date>2019-07-08</dc:date>
  <dc:description xmlns:ns0="xml" ns0:lang="en">The rational design of alternative antimicrobial materials with reduced toxicity toward  mammalian cells is highly desired due to the growing occurrence of bacteria resistant  to conventional antibiotics. A promising approach is the design of lipid‐based  antimicrobial nanocarriers. However, most of the commonly used polymer‐stabilized  nanocarriers are cytotoxic. Herein, the design of a novel, stabilizer‐free nanocarrier for  the human cathelicidin derived antimicrobial peptide LL‐37 that is cytocompatible and  promotes cell proliferation for improved wound healing is reported. The nanocarrier is  formed through the spontaneous integration of LL‐37 into novel, stabilizer‐free glycerol  mono‐oleate (GMO)‐based cubosomes. Transformations in the internal structure of  the cubosomes from Pn3m to Im3m‐type and eventually their transition into small  vesicles and spherical micelles are demonstrated upon the encapsulation of LL‐37  into their internal bicontinuous cubic structure using small angle X‐ray scattering,  cryogenic transmission electron microscopy, and light scattering techniques.  Additional in vitro biological assays show the antimicrobial activity of the stabilizer‐free  nano‐objects on a variety of bacteria strains, their cytocompatibility, and cell‐ proliferation enhancing effect. The results outline a promising strategy for the  comprehensive design of antimicrobial, cytocompatible lipid nanocarriers for the  protection and delivery of bioactive molecules with potential for application as  advanced wound healing materials.</dc:description>
  <dc:format>application/pdf</dc:format>
  <dc:identifier>https://folia.unifr.ch/global/documents/308116</dc:identifier>
  <dc:identifier>https://folia.unifr.ch/documents/308116/files/sal_mnb.pdf</dc:identifier>
  <dc:identifier>https://folia.unifr.ch/documents/308116/files/sal_mnb_sm.pdf</dc:identifier>
  <dc:language>eng</dc:language>
  <dc:relation>info:eu-repo/semantics/altIdentifier/doi/10.1002/adfm.201904007</dc:relation>
  <dc:rights>info:eu-repo/semantics/openAccess</dc:rights>
  <dc:rights>License undefined</dc:rights>
  <dc:source>Advanced Functional Materials. - 2019, p. 1904007</dc:source>
  <dc:subject>info:eu-repo/classification/udc/54</dc:subject>
  <dc:title xmlns:ns1="xml" ns1:lang="en">Multifunctional nano‐biointerfaces: cytocompatible antimicrobial nanocarriers from stabilizer‐free cubosomes</dc:title>
  <dc:type>http://purl.org/coar/resource_type/c_6501</dc:type>
</oai_dc:dc>