Jakubaszek, Marta Rossier, Jeremie Karges, Johannes Delasoie, Joachim Goud, Bruno Gasser, Gilles Zobi, Fabio 2019 The current photosensitizers (PSs) for photodynamic therapy (PDT) lack selectivity for cancer cells. To tackle this drawback, in view of selective cancer delivery, we envisioned conjugating two ruthenium polypyridyl complexes to vitamin B12 (Cobalamin, Cbl) to take advantage of the solubility and active uptake of the latter. Ultimately, our results showed that the transcobalamin pathway is unlikely involved for the delivery of these ruthenium‐based PDT PSs, emphasizing the difficulty in successfully delivering metal complexes to cancer cells. application/pdf https://folia.unifr.ch/global/documents/308091 https://folia.unifr.ch/documents/308091/files/zob_epc.pdf https://folia.unifr.ch/documents/308091/files/zob_epc_sm.pdf eng info:eu-repo/semantics/altIdentifier/doi/10.1002/hlca.201900104 info:eu-repo/semantics/openAccess License undefined Helvetica Chimica Acta. - 2019, vol. 102, no. 7, p. e1900104 info:eu-repo/classification/udc/54 Evaluation of the potential of cobalamin derivatives bearing ru(ii) polypyridyl complexes as photosensitizers for photodynamic therapy http://purl.org/coar/resource_type/c_6501