Tiam, Eric Robert Ngono Bikobo, Dominique Serge Zintchem, Auguste Abouem A. Mbabi Nyemeck II, Norbert Moni Ndedi, Esther Del Florence Betote Diboué, Patrick Hervé Nyegue, Maximilienne Ascension Atchadé, Alex de Théodore Pegnyemb, Dieudonné Emmanuel Bochet, Christian G. Koert, Ulrich 2019-03-04 Triclisinone (2), a new ochnaflavone derivative, was isolated from the aerial parts of Triclisia gilletii, along with known drypemolundein B (1) and eight other known compounds. The chemical shifts of drypemolundein B (1) have been partially revised based on reinterpretation of NMR spectroscopic data. The eight other secondary metabolites are composed of: (+)-nonacosan-10-ol (3); stigmasterol (4), 3-O-β-D- glucopyranosylsitosterol (5), 3-O-β-D-glucopyranosylstigmasterol (6); oleanic acid (7); myricetin (8), quercetin (9) and 3-methoxyquercetin (10). Their structures were elucidated using IR, MS, NMR 1D and 2D, 1H and 13C and comparison with literature data. Furthermore, compounds 1, 2, 5, 6, 8, 9 and the crude extract were tested against Mycobacterium tuberculosis. Compounds 1, 2, 8 and 9 displayed moderate to very good activity against resistant strain (codified AC 45) of M. tuberculosis with minimum inhibitory concentrations MICs ranging from 3.90 to 62.5 μg/mL. application/pdf https://folia.unifr.ch/global/documents/307909 https://folia.unifr.ch/documents/307909/files/boc_smt.pdf https://folia.unifr.ch/documents/307909/files/boc_smt_sm.pdf eng info:eu-repo/semantics/altIdentifier/doi/10.1080/14786419.2017.1402324 info:eu-repo/semantics/openAccess License undefined Natural Product Research. - 2019, vol. 33, no. 5, p. 642–650 info:eu-repo/classification/udc/57 Secondary metabolites from Triclisia gilletii (De Wild) Staner (Menispermaceae) with antimycobacterial activity against Mycobacterium tuberculosis http://purl.org/coar/resource_type/c_6501